INVIVO ASSESSMENT OF PITUITARY VOLUME WITH MAGNETIC-RESONANCE-IMAGING AND SYSTEMATIC STEREOLOGY - RELATIONSHIP TO DEXAMETHASONE SUPPRESSION TEST-RESULTS IN PATIENTS
INVIVO ASSESSMENT OF PITUITARY VOLUME WITH MAGNETIC-RESONANCE-IMAGING AND SYSTEMATIC STEREOLOGY - RELATIONSHIP TO DEXAMETHASONE SUPPRESSION TEST-RESULTS IN PATIENTS
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DOI：
10.1016/0165-1781(92)90070-j
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发表时间：
1992-10-01
影响因子：
11.3
通讯作者：
KRISHNAN, KRR
中科院分区：
文献类型：
--
作者：
AXELSON, DA;DORAISWAMY, PM;KRISHNAN, KRR
研究了 24 名住院精神科患者的地塞米松抑制试验 (DST) 结果与体内垂体体积之间的关系。使用系统体视学的原理，通过大脑的 3 毫米连续矢状自旋回波磁共振 (MR) 图像来测量垂体体积。垂体体积与下午 3 点之间没有相关性。或晚上 10 点地塞米松后（DEX 后）血浆皮质醇浓度。然而，当进行多元回归分析将垂体体积与性别、年龄和 DEX 后血浆皮质醇浓度联系起来时，发现垂体体积与年龄、性别和晚上 10 点之间存在显着关系。 DEX 后皮质醇血浆浓度。这是第一项证明直接测量而不是估计体内垂体体积的方法的研究。此外，它表明精神病患者下丘脑-垂体-肾上腺轴的激活（表现为 DEX 后皮质醇浓度升高）可能会影响垂体体积。
The relationship between dexamethasone suppression test (DST) results and in vivo pituitary volume was studied in 24 psychiatric inpatients. The principles of systematic stereology were used to measure pituitary volume from 3-mm contiguous sagittal spin-echo magnetic resonance (MR) images of the brain. There was no correlation between pituitary volume and 3 p.m. or 10 p.m. postdexamethasone (post-DEX) plasma cortisol concentrations. However, when multiple regression analysis was performed to relate pituitary volume to gender, age, and post-DEX plasma cortisol concentrations, there was a significant relationship between pituitary volume and age, gender, and 10 p.m. post-DEX cortisol plasma concentration. This is the first study to demonstrate a method that directly measures, rather than estimates, in vivo pituitary volume. Furthermore, it suggests that activation of the hypothalamic-pituitary-adrenal axis in psychiatric patients, as manifested by elevated post-DEX cortisol concentrations, may influence pituitary volume.