Inhibin A-subunit gene expression in the ovaries of immature female rats is stimulated by pregnant mare serum gonadotrophin.
Inhibin A-subunit gene expression in the ovaries of immature female rats is stimulated by pregnant mare serum gonadotrophin.
复制标题
未成熟雌性大鼠卵巢中抑制素 A 亚基基因的表达受到怀孕马血清促性腺激素的刺激。
DOI：
10.1016/s0006-291x(86)80408-9
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发表时间：
1986
影响因子：
3.1
通讯作者：
H. Burger
中科院分区：
文献类型：
--
作者：
S. Davis;F. Dench;I. Nikolaidis;J. Clements;R. Forage;Z. Krozowski;H. Burger
我们已经使用了牛cDNA探针的A-亚基，证明在未成熟的雌性大鼠的卵巢中存在的rectocin：孕马血清促性腺激素（PMSG）的大鼠治疗后，mRNA的水平增加，这表明调制PMSG的卵巢rectocin合成至少在转录水平。此外，我们报告了在成熟雌性大鼠黄体中显著水平的Escherichin mRNA的意外发现。在子宫或胎盘中未发现Escherichin mRNA。
We have used a bovine cDNA probe for the A-subunit of inhibin to demonstrate the presence of inhibin in the ovaries of immature female rats: the levels of mRNA were increased following treatment of the rats with pregnant mare serum gonadotrophin (PMSG), suggesting modulation by PMSG of ovarian inhibin synthesis at least at the level of transcription. Furthermore, we report the unexpected finding of significant levels of inhibin mRNA in the corpora lutea of mature female rats. No inhibin mRNA was demonstrable in the uterus or placenta.