Specific Removal of Monocytes from Peripheral Blood of Septic Patients by Polymyxin B-immobilized Filter Column.
Specific Removal of Monocytes from Peripheral Blood of Septic Patients by Polymyxin B-immobilized Filter Column.
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DOI：
10.18926/amo/31855
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发表时间：
2009-02
影响因子：
0.5
通讯作者：
M. Nishibori;Hideo Takahashi;H. Katayama;S. Mori;S. Saito;H. Iwagaki;N. Tanaka;K. Morita;A. Ohtsuka
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文献类型：
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作者：
M. Nishibori;Hideo Takahashi;H. Katayama;S. Mori;S. Saito;H. Iwagaki;N. Tanaka;K. Morita;A. Ohtsuka
内毒素是感染性休克的主要原因之一。固定化多粘菌素B的过滤柱（PMX）被开发用于通过直接血液灌流吸附内毒素，并已用于治疗LPS诱导的感染性休克。在这项研究中，我们表明，PMX也特异性结合单核细胞从败血症患者的外周血白细胞的结合细胞的免疫细胞化学和电子显微镜技术的分析手段。从脓毒症患者中特异性去除单核细胞可通过减少单核细胞与功能相关细胞（包括血管内皮细胞）之间的相互作用产生有益效果。
Lipopolysaccharide (LPS) is one of the major causes of septic shock. The polymyxin B-immobilized filter column (PMX) was developed for the adsorption of endotoxin by direct hemoperfusion and has been used for the treatment of LPS-induced septic shock. In this study, we demonstrated that PMX also specifically bound monocytes from the peripheral blood leukocytes of septic patients by mean of an analysis of bound cells using immunocytochemical and electron microscopic techniques. The specific removal of monocytes from septic patients may produce beneficial effects by reducing the interaction between monocytes and functionally associated cells including vascular endothelial cells.