Prematurity and perinatal adversity effects hypothalamic-pituitary-adrenal axis reactivity to social evaluative threat in adulthood.
Prematurity and perinatal adversity effects hypothalamic-pituitary-adrenal axis reactivity to social evaluative threat in adulthood.
复制标题
早产和围产期逆境会影响下丘脑-垂体-肾上腺轴对成年期社会评价威胁的反应性。
DOI：
10.1002/dev.21570
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发表时间：
2017
影响因子：
2.2
通讯作者：
Granger,DouglasA
中科院分区：
文献类型：
--
作者：
Sullivan,MaryC;Winchester,SuzyB;Bryce,CrystalI;Granger,DouglasA
这项研究考察了早产和围产期逆境对应激相关反应和HPA轴调节的个体差异的长期影响。研究对象为1985年至1989年间出生的健康早产儿(n= 20例)、内科疾病(n= 48例)、神经系统疾病(n= 26例)、小于胎龄儿(n= 24例)和足月儿(n= 37例)。在23岁时，在参加Trier社会压力测试之前和之后收集了多个唾液样本，后来进行了皮质醇的检测。结果显示，在23岁时，与足月、小于胎龄、患有内科疾病或健康的早产儿相比，早产儿有神经系统并发症的早产儿对社会评估威胁的皮质醇反应性更高。这些发现对当代理论的影响进行了讨论，这些理论提出了早期逆境对生物敏感性和易感性的影响，这些理论将经验转化为与健康不良和疾病风险相关的发育结果。
This study examined the long‐term effects of prematurity and perinatal adversity on individual differences in stress‐related reactivity and regulation of the HPA axis. A prospective sample of 155 infants born preterm and healthy (n= 20), medical illness (n= 48), neurological illness (n= 26), and small for gestational age (n= 24) and full‐term (n= 37) were recruited between 1985 and 1989. At age 23 years, multiple saliva samples were collected before and after participation in the Trier Social Stress Test and later assayed for cortisol. Results reveal that at age 23 years, infants born premature with neurological complications showed higher cortisol reactivity to social evaluative threat compared to either their full‐term, small for gestation age, medically ill, or healthy preterm peers. Findings are discussed in terms of implications for contemporary theories that propose effects of early adversity on biological sensitivities and susceptibilities, which translate experience into developmental outcomes related to poor health and risk for disease.