EEG spectral analysis of wakefulness and REM sleep in high functioning autistic spectrum disorders
EEG spectral analysis of wakefulness and REM sleep in high functioning autistic spectrum disorders
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DOI：
10.1016/j.clinph.2004.01.011
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发表时间：
2004-06-01
影响因子：
4.7
通讯作者：
Godbout, R
中科院分区：
文献类型：
--
作者：
Daoust, AM;Limoges, T;Godbout, R
目的：应用快速眼动睡眠和清醒脑电技术，探讨自闭症谱系障碍(ASD)患者的颞枕区参与其发病机制。方法：采用12电极蒙太奇技术，记录9例ASD患者和8例正常对照的脑电。对REM睡眠和清醒两种激活状态下记录的脑电活动进行频谱分析(0.75~19.75 Hz)。结果：与对照组相比，ASD患者在REM睡眠时，其初级(O-1，O-2)和联合(T-5，T-6)皮层视区的绝对β(13.0-19.75 Hz)频谱幅度明显低于对照组。在夜间清醒时，ASD患者左额叶极区(FP1)的绝对theta(4.0-7.75 Hz)频谱幅度显著高于对照组，但在清晨清醒时不明显。意义：清醒EEG的结果与先前报道的ASD额叶不典型的神经心理学迹象一致；来自REM睡眠的结果是第一个支持ASD视觉操作功能异常假说的EEG证据。总而言之，这些结果指向非典型的丘脑-皮质机制，辅助ASD的神经信息处理。(C)2004年国际临床神经生理学联合会。爱思唯尔爱尔兰有限公司出版。版权所有。
Objective: The aim of this study was to investigate the involvement of temporo-occipital regions in the pathophysiology of autistic spectrum disorders (ASD) by using REM sleep and waking EEG.Methods: The EEG recordings of 9 persons with ASD and 8 control participants were recorded using a 12-electrode montage. Spectral analysis (0.75-19.75 Hz) was performed on EEG activity recorded upon two activated states: REM sleep and wakefulness.Results: During REM sleep, persons with ASD showed a selective, significantly lower absolute beta (13.0-19.75 Hz) spectral amplitude over the primary (O-1, O-2) and associative (T-5, T-6) cortical visual areas compared to controls. Persons with ASD showed significantly higher absolute theta (4.0-7.75 Hz) spectral amplitude over the left frontal pole region (Fp1) compared to controls during evening wakefulness, but not during morning wakefulness.Significance: The results of waking EEG are consistent with previously reported observations of neuropsychological signs of frontal atypicalities in ASD; results from REM sleep are the first EEG evidence to support the hypothesis of abnormal visuoperceptual functioning in ASD. Altogether, these results point toward atypical thalamo-cortical mechanisms subserving the neural processing of information in ASD. (C) 2004 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.