Corneal swelling at low atmospheric oxygen pressures.
Corneal swelling at low atmospheric oxygen pressures.
复制标题
低气压下角膜肿胀。
DOI：
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发表时间：
1980
影响因子：
4.4
通讯作者：
R. Farrell
中科院分区：
文献类型：
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作者：
R. Mandell;R. Farrell
将28名受试者的角膜暴露于6.9、17.1或22.2 mm Hg的氧气分压下，并通过角膜厚度测量法测量角膜肿胀4 h。在最初的上升之后，肿胀在约3 h后稳定;在许多受试者中，它被逆转，表明适应过程。4小时后，三种氧分压下的平均角膜肿胀分别为5.07%、2.13%和1.66%。防止角膜肿胀的平均最低需氧量至少为23 mm Hg，并且个体之间差异很大。肿胀反应的变化足以解释在缺乏足够的泪液泵送的情况下配戴透氧角膜接触镜的患者水肿的临床差异。
Corneas of 28 human subjects were exposed to oxygen partial pressures, in a gas goggle, of either 6.9, 17.1, or 22.2 mm Hg, and the corneal swelling was measured by pachometry for 4 hr. Following an initial rise, the swelling stabilized after about 3 hr; in many subjects it was reversed, indicating an adaptation process. The average corneal swelling after 4 hr for the three oxygen partial pressures was 5.07%, 2.13%, and 1.66%, respectively. The average minimum oxygen requirement to prevent corneal swelling was at least 23 mm Hg and varied significantly among individuals. The variations in swelling responses were large enough to explain clinical differences in edema of patients wearing oxygen-permeable contact lenses, in the absence of adequate tear pumping.