Social setting, social rank and HPA axis response in cynomolgus monkeys.
Social setting, social rank and HPA axis response in cynomolgus monkeys.
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DOI：
10.1007/s00213-017-4596-7
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发表时间：
2017-06
影响因子：
3.4
通讯作者：
Grant KA
中科院分区：
文献类型：
--
作者：
Jimenez VA;Allen DC;McClintick MN;Grant KA
下丘脑-垂体-肾上腺（HPA）轴的活动在不同的社会环境下，在非人灵长类动物的研究不足。评价不同社会环境下雄性食蟹猴垂体-肾上腺激素（促肾上腺皮质激素（ACTH）和皮质醇）对HPA轴药理学挑战的反应。雄性食蟹猴（Macaca fascicularis，n=11）在阿坝设计中连续数月交替单独圈养（A）和群居圈养（B）。在每个实验阶段，血浆促肾上腺皮质激素和皮质醇的测量响应于低和轻度强度的心理应激和以下管理的盐水，纳洛酮，绵羊促肾上腺皮质激素释放因子（oCRF）和地塞米松。这些数据表明，在低压力条件下测量的皮质醇是敏感的社会等级（优势层次），并区分占主导地位的非占主导地位的动物在个人和社会设置。纳洛酮给药导致循环ACTH和皮质醇升高，而oCRF仅增加循环皮质醇。在社会住房期间，皮质醇对纳洛酮和oCRF的反应增加，而地塞米松对ACTH和皮质醇的抑制在所有社会环境中保持一致。在非人类灵长类动物中，循环ACTH和皮质醇对社会环境变化的敏感性不同。皮质醇反应增加社会住房，可以刺激纳洛酮和oCRF，而ACTH反应一般不受社会环境或oCRF的影响，但纳洛酮增加。这些数据表明肾上腺和垂体对社会环境变化的反应不同，社会优势的影响很小，但一致。
Hypothalamic-pituitary-adrenal (HPA) axis activity under different social settings in non-human primates is understudied. Evaluate the response of pituitary-adrenal hormones (adrenocorticotropic hormone (ACTH) and cortisol) to pharmacological challenges of the HPA axis in male cynomolgus macaques under different social settings. Male cynomolgus macaques (Macaca fascicularis, n=11) were individually (A) and socially housed (B) in alternation, over consecutive months, in an ABA design. During each experimental phase, plasma ACTH and cortisol were measured in response to low and mild intensity psychological stressors and following administration of saline, naloxone, ovine-corticotropin-releasing factor (oCRF) and dexamethasone. These data demonstrate that cortisol measured under low stress conditions is sensitive to social rank (dominance hierarchy) and distinguishes dominant from non-dominant animals during both individual and social settings. Administration of naloxone resulted in elevated circulating ACTH and cortisol, while oCRF only increased circulating cortisol. During social housing, the cortisol response to naloxone and oCRF was increased, whereas dexamethasone suppression of ACTH and cortisol remained consistent across all social settings. Circulating ACTH and cortisol are differentially sensitive to changes in social settings in non-human primates. Cortisol response increased during social housing and could be stimulated by both naloxone and oCRF, whereas ACTH response was generally not influenced by social setting or oCRF but was increased by naloxone. These data show differential adrenal and pituitary response to changes in social settings and a small, but consistent, effect of social dominance.