Potential roles of eosinophils in cancer therapy: epidemiological studies, experimental models, and clinical pathology.
Potential roles of eosinophils in cancer therapy: epidemiological studies, experimental models, and clinical pathology.
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DOI：
10.2174/1574892808666131118232656
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发表时间：
2014-05
影响因子：
2.8
通讯作者：
C. Cao;Yangjun Gu;Chen Zhu;T. Palmai-Pallag;F. Lan;Zhihua Chen;Wen Li;Huahao Shen;S. Ying-S.-Y
中科院分区：
文献类型：
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作者：
C. Cao;Yangjun Gu;Chen Zhu;T. Palmai-Pallag;F. Lan;Zhihua Chen;Wen Li;Huahao Shen;S. Ying-S.-Y
嗜酸性粒细胞在过敏性疾病和蠕虫感染中起重要作用。作为多功能白细胞，嗜酸性粒细胞也被指示在抗癌免疫中。已发表的研究表明，过敏性疾病与许多恶性肿瘤风险降低的趋势之间存在关联。此外，肿瘤组织中的嗜酸性粒细胞浸润被认为是一个独立的预后因素。嗜酸性粒细胞通常被募集到肿瘤部位，其中嗜酸性粒细胞颗粒蛋白和细胞因子在活化时释放，这反过来又损伤和杀死肿瘤细胞。在过去的十年中，已经授予了许多基于使用嗜酸性细胞因子的潜在癌症治疗的专利。在这篇文章中，我们回顾了目前的研究结果，流行病学，实验模型，临床病理学和分子机制参与嗜酸性粒细胞对癌症的反应。此外，我们讨论了有前途的靶向治疗与嗜酸性细胞因子作为一个新的角度来对抗癌症。
Eosinophils play important roles in allergic diseases as well as during helminth infection. As multifunctional leukocytes, eosinophils have also been indicated in anti-cancer immunity. Published studies have suggested an association between allergic conditions and a trend of decreased risk in numerous malignances. Moreover, eosinophil infiltration in tumor tissue is considered an independent prognostic factor. Eosinophils are often recruited to tumor sites, where eosinophil granule proteins and cytokines are released upon activation, which in turn damage and kill tumor cells. In the last decade, a number of patents based on potential cancer therapy using eosinophilic cytokines have been awarded. In this article, we review the current findings on epidemiology, experimental models, clinical pathology, and molecular mechanisms involved in the response of eosinophils towards cancer. Moreover, we discuss promising targeted therapies with eosinophilic cytokines as a novel perspective to combat cancer.