Prolonged varicella-zoster virus reinfection in an adult after unrelated cord blood transplantation.
Prolonged varicella-zoster virus reinfection in an adult after unrelated cord blood transplantation.
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DOI：
10.4103/0019-5154.100500
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发表时间：
2012-09
影响因子：
1.7
通讯作者：
Nishigori C
中科院分区：
文献类型：
--
作者：
Oka M;Kunisada M;Oba Y;Okamura A;Nishigori C
脐带血移植（CBT）后大多数水痘带状疱疹病毒（VZV）感染表现为局部带状疱疹。在这里，我们报告了一名成年患者在 CBT 后再次感染 VZV 的病例，临床上表现为水痘。一名 50 岁的日本男性因治疗急性淋巴细胞白血病而接受 CBT。十七个月后，他出现了少量带有脐状中心的囊泡。皮肤活检显示表皮内水疱含有退化的气球细胞。随后，他的全身都出现了皮疹。患者接受静脉注射阿昔洛韦治疗 5 天，随后口服伐昔洛韦治疗 9 天。大部分皮损需要3周多才能结痂。皮疹发作后第3天和第33天抗VZV IgG血清水平分别为阴性和260 mIU/ml。第 3 天和第 33 天的血清抗 VZV IgM 未检测到。我们的患者被诊断为水痘带状疱疹病毒再感染。
Most varicella-zoster virus (VZV) infections after cord blood transplantation (CBT) present as localized herpes zoster. Here, we report a case of VZV reinfection in an adult patient after CBT that appeared clinically to be varicella. A 50-year-old Japanese man underwent CBT for the management of acute lymphoblastic leukemia. Seventeen months later, he developed a small number of vesicles with umbilicated centers. A skin biopsy showed an intraepidermal blister containing degenerated balloon cells. Subsequently, the skin eruption developed over his entire body. The patient was treated with intravenous acyclovir for 5 days, followed by oral valacyclovir for 9 days. It took more than 3 weeks for most of the skin lesions to scab. Serum levels of anti-VZV IgG on days 3 and 33 after the onset of the skin eruption were negative and 260 mIU/ml, respectively. Serum anti-VZV IgM on days 3 and 33 was not detected. Our patient was diagnosed with VZV reinfection.