Metabolic and cardiovascular implications of a metabolically healthy obesity phenotype.
Metabolic and cardiovascular implications of a metabolically healthy obesity phenotype.
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DOI：
10.3803/enm.2014.29.4.427
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发表时间：
2014-12-29
期刊：
影响因子：
--
通讯作者：
Rhee EJ
中科院分区：
文献类型：
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作者：
Seo MH;Rhee EJ
代谢健康性肥胖（MHO）是一个新的概念，其中个体可以在没有任何代谢异常的情况下表现出肥胖表型。MHO有许多定义，它们使用各种组件。临床和基础研究的结果表明，与正常体重对照组相比，MHO受试者未表现出死亡率增加、心血管疾病风险增加或2型糖尿病风险增加。虽然这些发现意味着代谢健康是比肥胖更重要的因素，但一些研究表明，MHO受试者与代谢不健康的肥胖受试者具有相似的代谢或心血管疾病风险。因此，仍然存在争论，不仅对MHO表型的影响，但它的存在。因此，未来的研究应该集中在制定一个统一的定义MHO和区分谁将在代谢和心血管疾病的高风险的主题。
Metabolically healthy obesity (MHO) is a new concept in which an individual may exhibit an obese phenotype in the absence of any metabolic abnormalities. There are a number of definitions of MHO that utilize a variety of components. The findings of clinical and basic studies indicate that subjects with MHO do not exhibit an increased mortality, an increased risk of cardiovascular disease, or an increased risk of type 2 diabetes mellitus, as compared to normal-weight controls. Although these findings imply that metabolic health is a more important factor than obesity, several studies have shown that subjects with MHO have a similar risk of metabolic or cardiovascular diseases as those with metabolically unhealthy obesity. Thus, there is still debate regarding not only the implications of the MHO phenotype but its very existence. Accordingly, future studies should focus on developing a unified definition of MHO and distinguishing subjects who will be at a high risk for metabolic and cardiovascular diseases.