Metabolomic studies of Pseudomonas aeruginosa
Metabolomic studies of Pseudomonas aeruginosa
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DOI：
10.1007/s11274-019-2739-1
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发表时间：
2019-11-01
影响因子：
4.1
通讯作者：
Mlynarz, Piotr
中科院分区：
文献类型：
--
作者：
Mielko, Karolina Anna;Jablonski, Slawomir Jan;Mlynarz, Piotr
铜绿假单胞菌是一种常见的革兰氏阴性环境生物。它可能是人类严重感染的重要致病因素，特别是在囊性纤维化患者中。由于其对抗生素的天然抗性和形成生物膜的能力，感染这种病原体可能导致严重的治疗问题。近年来，铜绿假单胞菌的代谢组学研究已经进行。本文就代谢组学方法在细菌鉴定、分化、基因组与代谢组的相互联系、外界因素对细菌代谢组的影响以及铜绿假单胞菌新代谢产物的鉴定等方面的研究进展进行综述。所有这些研究都可能提供有关代谢途径的有价值的信息，从而了解细菌菌株对宿主环境的适应性，这可能导致新药物开发和/或制定新的假单胞菌治疗和诊断策略。[图形]。
Pseudomonas aeruginosa is a common, Gram-negative environmental organism. It can be a significant pathogenic factor of severe infections in humans, especially in cystic fibrosis patients. Due to its natural resistance to antibiotics and the ability to form biofilms, infection with this pathogen can cause severe therapeutic problems. In recent years, metabolomic studies of P. aeruginosa have been performed. Therefore, in this review, we discussed recent achievements in the use of metabolomics methods in bacterial identification, differentiation, the interconnection between genome and metabolome, the influence of external factors on the bacterial metabolome and identification of new metabolites produced by P. aeruginosa. All of these studies may provide valuable information about metabolic pathways leading to an understanding of the adaptations of bacterial strains to a host environment, which can lead to new drug development and/or elaboration of new treatment and diagnostics strategies for Pseudomonas.[GRAPHICS].