THE NATURE, DISTRIBUTION AND CAUSES OF TRAUMATIC BRAIN INJURY
THE NATURE, DISTRIBUTION AND CAUSES OF TRAUMATIC BRAIN INJURY
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DOI：
10.1111/j.1750-3639.1995.tb00618.x
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发表时间：
1995-10-01
期刊：
影响因子：
6.4
通讯作者：
GENNARELLI, TA
中科院分区：
文献类型：
--
作者：
GRAHAM, DI;ADAMS, JH;GENNARELLI, TA
鉴定和解释非导弹头部损伤引起的脑损伤往往是不容易的，其结果是，最明显的结构性损伤确定死后可能不是最重要的，试图建立临床病理学的相关性。例如，如果没有其他类型的脑损伤，成功治疗的颅骨骨折、相当严重的脑挫伤或大颅内血肿患者可以顺利完全康复。然而，并非罕见的更微妙的病理形式存在，只能在显微镜下识别。因此，需要通过尸检采取系统和务实的方法，并认识到需要以适合细胞和分子研究的方式保留组织。
The identification and interpretation of brain damage resulting from a non-missile head injury is often not easy with the result that the most obvious structural damage identified postmortem may not be the most important in trying to establish clinicopathological correlations. For example patients with a fracture of the skull, quite severe cerebral contusions or a large intracranial haematoma that is successfully treated can make an uneventful and complete recovery if no other types of brain damage are present. However, not infrequently more subtle forms of pathology are present and ones that can only be identified microscopically. A systematic and pragmatic approach through the autopsy is therefore required and one that recognises the need for tissue to be retained in ways that are appropriate for cellular and molecular studies.