Impact of supplemental site grants to increase African American accrual for the Selenium and Vitamin E Cancer Prevention Trial
Impact of supplemental site grants to increase African American accrual for the Selenium and Vitamin E Cancer Prevention Trial
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DOI：
10.1177/1740774509357227
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发表时间：
2010-02-01
期刊：
影响因子：
2.7
通讯作者：
Minasian, Lori M.
中科院分区：
文献类型：
--
作者：
Cook, Elise D.;Arnold, Kathryn B.;Minasian, Lori M.
背景非裔美国人应计预防试验的速度代表的疾病负担，这一人口需要额外的资源和集中的efforts.Purpose描述的理由，背景和标准选择的网站，收到少数招募增强赠款（MREG），以增加非裔美国人的招募硒和维生素E癌症预防试验（SELECT）。为了确定非洲裔美国人的应计费用较高的15个MREG网站相比，类似的nonawarded sites.Methods在非洲裔美国人应计费用的变化在网站收到MREG的变化进行了比较，在一组的15个，频率匹配，nonawarded网站使用准实验，事后分析。成功和不成功的招聘策略报告的MREG网站的prescribed.Results增加的非洲裔美国人参与者的数量，每月累计在MREG网站后的资金高于在比较网站的变化的一个因素为3.38（p = 0.004，95%CI：1.51-7.57）。由于MREG的资助，估计在MREG研究中心额外招募了602名非裔美国人参与者，占总招募人数的14.9%。成功的招募策略MREG网站报道，包括增加工作人员，交通资源，通过媒体，邮件，和前列腺癌筛查诊所在下班时间招募。尽管选择的比较研究中心在潜在混杂因素方面与MREG研究中心相似，但未知因素可能会产生偏倚结果。成本效益的分析没有进行。结论MREG网站增加非裔美国人应计在后融资期间比比较网站，表明MREG资金增强了网站的能力，以增加非裔美国人的参与者。有针对性的赠款早期的应计期可能是一个有用的多站点的干预措施，以增加非洲裔美国人的预防研究，其中足够的非洲裔美国人的代表性是必不可少的。临床试验2010; 7：90-99。http://ctj.sagepub.com.
Background African American accrual to prevention trials at rates representative of the disease burden experienced by this population requires additional resources and focused efforts.Purpose To describe the rationale, context, and criteria for selection of sites that received Minority Recruitment Enhancement Grants (MREGs) to increase African American recruitment to the Selenium and Vitamin E Cancer Prevention Trial (SELECT). To determine if African American accrual was higher among the 15 MREG sites when compared with similar nonawarded sites.Methods Changes in African American accrual at sites that received MREGs are compared with changes in a group of 15, frequency-matched, nonawarded sites using a quasi-experimental, post hoc analysis. Successful and unsuccessful recruitment strategies reported by the MREG sites are described.Results The increased number of African American participants accrued per month at MREG sites post-funding was higher than the change at comparison sites by a factor of 3.38 (p = 0.004, 95% CI: 1.51-7.57). An estimated 602 additional African American participants were recruited at MREG sites due to MREG funding, contributing to the overall 14.9% African American recruitment. Successful recruitment strategies most reported by MREG sites included increasing staff, transportation resources, recruiting through the media, mailings, and prostate cancer screening clinics during off-hours.Limitations Comparison sites were chosen retrospectively, not by randomization. Although comparison sites were selected to be similar to MREG sites with regard to potential confounding factors, it is possible that unknown factors could have biased results. Cost-effective analyses were not conducted.Conclusions MREG sites increased African American accrual in the post-funding period more than comparison sites, indicating MREG funding enhanced the sites' abilities to accrue African American participants. Targeted grants early in the accrual period may be a useful multi-site intervention to increase African American accrual for a prevention study where adequate African American representation is essential. Clinical Trials 2010; 7: 90-99. http://ctj.sagepub.com.