Host switch leads to emergence of Plasmodium vivax malaria in humans
Host switch leads to emergence of Plasmodium vivax malaria in humans
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DOI：
10.1093/molbev/msi160
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发表时间：
2005-08-01
影响因子：
10.7
通讯作者：
Su, XZ
中科院分区：
文献类型：
--
作者：
Mu, JB;Joy, DA;Su, XZ
间日疟原虫是人类分布最广泛的疟疾寄生虫，其地理起源存在争议。虽然系统发育分析已经证实了间日疟原虫与亚洲灵长类疟疾的遗传亲缘关系，但间日疟原虫与新大陆灵长类疟疾新大陆间日疟原虫的遗传相似性表明，人类可能是从新大陆猴子那里感染了间日疟原虫，反之亦然。此外，西非和中非Duffy阴性血型(FY X B-Null/Fy X B-Null)的接近固定与定向选择一致，以及Duffy阴性血型与对间日疟的完全抗药性相关联，表明非洲宿主-寄生虫共同进化的时间较长。在这里，我们使用贝叶斯和似然方法，结合共同进化图谱，从176个分离株和几个密切相关的疟原虫物种的完整线粒体基因组中重建间日疟原虫的遗传和共同进化史。综上所述，单倍型网络、寄生虫迁移模式、人口学历史和共同进化图谱支持通过猕猴的宿主切换而起源于亚洲。
The geographical origin of Plasmodium vivax, the most widespread human malaria parasite, is controversial. Although genetic closeness to Asian primate malarias has been confirmed by phylogenetic analyses, genetic similarities between P. vivax and Plasmodium simium, a New World primate malaria, suggest that humans may have acquired P. vivax from New World monkeys or vice versa. Additionally, the near fixation of the Duffy-negative blood type (FY X B-null/FY X B-null) in West and Central Africa, consistent with directional selection, and the association of Duffy negativity with complete resistance to vivax malaria suggest a prolonged period of host-parasite coevolution in Africa. Here we use Bayesian and likelihood methods in conjunction with cophylogeny mapping to reconstruct the genetic and coevolutionary history of P. vivax from the complete mitochondrial genome of 176 isolates as well as several closely related Plasmodium species. Taken together, a haplotype network, parasite migration patterns, demographic history, and cophylogeny mapping support an Asian origin via a host switch from macaque monkeys.