The Association Between Financial Toxicity and Treatment Regret in Men With Localized Prostate Cancer.
The Association Between Financial Toxicity and Treatment Regret in Men With Localized Prostate Cancer.
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DOI：
10.1093/jncics/pkac071
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发表时间：
2022-11-01
影响因子：
4.4
通讯作者：
中科院分区：
文献类型：
--
作者：
财务毒性正在成为一个以患者为中心的重要结果，但在前列腺癌患者中研究不足。我们试图了解患有局限性前列腺癌的男性患者的经济负担和治疗遗憾之间的关系，以更好地评估财务讨论在患者咨询中的作用。利用手术和放射治疗的比较效果分析数据集，我们确定了2011至2012年间所有接受手术、放射治疗或积极监测局限性前列腺癌的男性。在3年和5年的随访中评估经济负担和治疗遗憾。通过控制人口统计学和疾病特征、治疗、功能结果和患者期望的多变量纵向Logistic回归来评估经济负担和悔恨之间的关系。在2924名符合条件的患者中，81%的患者可以进行3年和/或5年随访的后悔和经济负担评估(n = 2359)。调整相关协变量后，在3个 年中，来自“一般经济”的经济负担与治疗遗憾有关(优势比[OR]=2.47，95%可信区间[CI]=1.3 3~4.5 7；P = .0.0 4)；但在5年随访时，这种联系不再具有统计学意义(OR=1.19，95%CI=0.5 6~2.5 4；P = .7)。在这个以人群为基础的男性局限性前列腺癌患者样本中，我们观察到了经济负担和治疗遗憾之间的关联。我们的发现表明，间接治疗费用，特别是在确诊后的前3年，可能比直接费用对患者的影响更深远，对于共同决策是重要的。
Financial toxicity is emerging as an important patient-centered outcome and is understudied in prostate cancer patients. We sought to understand the association between financial burden and treatment regret in men with localized prostate cancer to better evaluate the role of financial discussions in patient counseling. Utilizing the Comparative Effectiveness Analysis of Surgery and Radiation dataset, we identified all men accrued between 2011 and 2012 who underwent surgery, radiation, or active surveillance for localized prostate cancer. Financial burden and treatment regret were assessed at 3- and 5-year follow-up. The association between financial burden and regret was assessed using multivariable longitudinal logistic regression controlling for demographic and disease characteristics, treatment, functional outcomes, and patient expectations. Of the 2924 eligible patients, regret and financial burden assessments for 3- and/or 5-year follow-up were available for 81% (n = 2359). After adjustment for relevant covariates, financial burden from “finances in general” was associated with treatment regret at 3 years (odds ratio [OR] = 2.47, 95% confidence interval [CI] = 1.33 to 4.57; P = .004); however, this association was no longer statistically significant at 5-year follow-up (OR = 1.19, 95% CI = 0.56 to 2.54; P = .7). In this population-based sample of men with localized prostate cancer, we observed associations between financial burden and treatment regret. Our findings suggest indirect treatment costs, especially during the first 3 years after diagnosis, may impact patients more profoundly than direct costs and are important for inclusion in shared decision making.
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DOI：
10.1016/j.urolonc.2013.10.011
发表时间：
2014-05-01
影响因子：
2.7
作者：
Collingwood, Shemille A.;McBride, Russell B.;Samadi, David B.
通讯作者：
Samadi, David B.
影响因子：
2.1
作者：
Lindsay, Jamie;Uribe, Santiago;Kusuma, Venkata R. M.
通讯作者：
Kusuma, Venkata R. M.
影响因子：
6.2
作者：
Kale, Hrishikesh P.;Carroll, Norman V.
通讯作者：
Carroll, Norman V.
影响因子：
8.2
作者：
van Stam, Marie-Anne;Aaronson, Neil K.;van der Poel, Henk G.
通讯作者：
van der Poel, Henk G.
影响因子：
3
作者：
MCHORNEY, CA;WARE, JE;RACZEK, AE
通讯作者：
RACZEK, AE