The mammalian Odz gene family:: Homologs of a Drosophila pair-rule gene with expression implying distinct yet overlapping developmental roles
The mammalian Odz gene family:: Homologs of a Drosophila pair-rule gene with expression implying distinct yet overlapping developmental roles
复制标题
DOI：
10.1006/dbio.1999.9532
复制
发表时间：
2000-01-01
影响因子：
2.7
通讯作者：
Wides, R
中科院分区：
文献类型：
--
作者：
Ben-Zur, T;Feige, E;Wides, R
果蝇配对规则基因odz（Tenm）在整个发育过程中具有许多模式化作用。我们已经鉴定了该基因的四种哺乳动物同源物，包括先前描述为小鼠ER应激反应基因的一种，Doc 4（Wang et al.，1998年）。Odz基因编码的大多肽显示果蝇Odz的标志：一个假定的信号肽; 8个EGF样重复;和一个假定的跨膜结构域，随后是一个1800个氨基酸的延伸，与该家族以外的任何蛋白质都没有同源性。小鼠基因Odz 3和Doc 4/Odz 4表现出部分重叠，但明显不同的胚胎表达模式。主要的胚胎表达部位在神经系统，包括顶盖、视神经隐窝、视柄和发育中的眼睛。另外的表达位点包括气管和中胚层来源的组织，如肠系膜，以及形成肢体和骨。Odz 2基因的表达仅限于神经系统。表达模式表明，每个基因都有自己独特的发育作用。果蝇和脊椎动物Odz表达模式的比较表明进化保守的功能。(C)北京大学出版社.
The Drosophila pair-rule gene odz (Tenm) has many patterning roles throughout development. We have identified four mammalian homologs of this gene, including one previously described as a mouse ER stress response gene, Doc4 (Wang et al., 1998). The Odz genes encode large polypeptides displaying the hallmarks of Drosophila Odz: a putative signal peptide; eight EGF-like repeats; and a putative transmembrane domain followed by a 1800-amino-acid stretch without homology to any proteins outside of this family. The mouse genes Odz3 and Doc4/Odz4 exhibit partially overlapping, but clearly distinct, embryonic expression patterns. The major embryonic sites of expression are in the nervous system, including the tectum, optic recess, optic stalk, and developing eye. Additional sites of expression include trachea and mesodermally derived tissues, such as mesentery, and forming limb and bone. Expression of the Odz2 gene is restricted to the nervous system. The expression patterns suggest that each of the genes has its own distinct developmental role. Comparisons of Drosophila and vertebrate Odz expression patterns suggest evolutionarily conserved functions. (C) 2000 Academic Press.