Common psychiatric disorders share the same genetic origin: a multivariate sibling study of the Swedish population
Common psychiatric disorders share the same genetic origin: a multivariate sibling study of the Swedish population
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DOI：
10.1038/mp.2015.116
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发表时间：
2016-05-01
影响因子：
11
通讯作者：
Lichtenstein, P.
中科院分区：
文献类型：
--
作者：
Pettersson, E.;Larsson, H.;Lichtenstein, P.
最近的研究表明，不同的心理健康问题似乎部分受到同一组基因的影响，这些基因可以用一个普通的遗传因素来概括。到目前为止，这类研究一直依赖于对社区样本的调查，这可能会引入潜在的偏见。这项研究的目的是检验当基于与先前研究不同的偏见的不同的确定方法时，是否仍然会出现一般的遗传因素。我们以瑞典的所有成年人(n=3 475 112)为目标，使用国家登记，并确定那些在寻求或被迫进入精神卫生保健后接受一种或多种精神诊断的人。为了检查一般因素的遗传与环境病因，我们检查了参与者的同父异母或同父异母的兄弟姐妹是否也得到了诊断。根据国际疾病分类，我们重点关注了八种主要的精神障碍，包括精神分裂症、分裂情感障碍、躁郁症、抑郁、焦虑、注意力缺陷/多动障碍、酒精使用障碍和药物滥用。此外，我们还包括对暴力犯罪的定罪。多变量分析表明，一般遗传因素影响所有暴力犯罪的障碍和定罪，占条件差异的10%(注意力缺陷/多动障碍)至36%(药物滥用)。因此，在调查和国家登记的基础上，出现了精神病理学的一般遗传因素，表明一组多效性基因影响各种精神障碍。
Recent studies have shown that different mental-health problems appear to be partly influenced by the same set of genes, which can be summarized by a general genetic factor. To date, such studies have relied on surveys of community-based samples, which could introduce potential biases. The goal of this study was to examine whether a general genetic factor would still emerge when based on a different ascertainment method with different biases from previous studies. We targeted all adults in Sweden (n = 3 475 112) using national registers and identified those who had received one or more psychiatric diagnoses after seeking or being forced into mental health care. In order to examine the genetic versus environmental etiology of the general factor, we examined whether participants' full-or half-siblings had also received diagnoses. We focused on eight major psychiatric disorders based on the International Classification of Diseases, including schizophrenia, schizoaffective disorder, bipolar disorder, depression, anxiety, attention-deficit/hyperactivity disorder, alcohol use disorder and drug abuse. In addition, we included convictions of violent crimes. Multivariate analyses demonstrated that a general genetic factor influenced all disorders and convictions of violent crimes, accounting for between 10% (attention-deficit/hyperactivity disorder) and 36% (drug abuse) of the variance of the conditions. Thus, a general genetic factor of psychopathology emerges when based on both surveys as well as national registers, indicating that a set of pleiotropic genes influence a variety of psychiatric disorders.