Associations between birth weight, preeclampsia and cognitive functions in middle-aged adults.
Associations between birth weight, preeclampsia and cognitive functions in middle-aged adults.
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DOI：
10.1017/s2040174411000596
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发表时间：
2011-12
影响因子：
1.7
通讯作者：
Goldstein J
中科院分区：
文献类型：
--
作者：
Factor-Litvak P;Straka N;Cherkerzian S;Richards M;Liu X;Sher A;Neils G;Goldstein J
Exposure to prenatal inflammation, measured using proxies such as preterm birth, low birth weight and maternal preeclampsia, has been associated with decrements in scores on tests of intelligence in children and adolescents. We examined whether these decrements persist into middle adulthood and expand into other domains of cognitive functioning. Using data from the Early Determinants of Adult Health project and from the ancillary project, Fetal Antecedents of Major Depression and Cardiovascular Disease, we selected term same sex sibling sets or singletons from these sets, from the New England Family Study (NEFS) and the Child Health and Development Studies (CHDS), discordant on either fetal growth or preeclampsia to test the hypotheses that prenatal exposure to inflammation was associated with decrements in attention, learning and executive function 40 years later. Exposure was defined as a continuous measure of percentile birth weight for gestational age, fetal growth restriction (< 20th percentile of birth weight for gestational age) or maternal preeclampsia. Given that the sample was comprised, in part, of sibling sets, the analyses were performed using mixed models to account for the inter-sibling correlations. Analyses were performed separately by study site (i.e. NEFS and CHDS). In the NEFS we found a small association between fetal growth restriction and working memory for males, such that the working memory score declined by 1.5 points (95% CI -2.4, -0.27). This association was significantly different from the estimated association in females. We discuss the possible reasons for this association which include the possible mediating effects of the postnatal environment.
