Lifelong SIRT-1 overexpression attenuates large artery stiffening with advancing age
Lifelong SIRT-1 overexpression attenuates large artery stiffening with advancing age
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DOI：
10.18632/aging.103322
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发表时间：
2020-06-30
期刊：
影响因子：
5.2
通讯作者：
Donato, Anthony J.
中科院分区：
文献类型：
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作者：
Machin, Daniel R.;Auduong, Yauling;Donato, Anthony J.
高龄伴有主动脉硬化，这与sirtuin-1（SIRT-1）的血管表达减少有关。增加SIRT-1表达的干预措施也降低了年龄相关的主动脉僵硬度。因此，我们试图确定终身SIRT-1过表达是否会减弱年龄相关的主动脉硬化。在SIRT-1转基因过表达（SIRTTG）和野生型（WT）小鼠中评估3-24个月的主动脉脉搏波速度（PWV）。为了确定主动脉结构变化对主动脉硬化的作用，进行了主动脉壁特征的组织学评估。在整个年龄范围内（3-24个月），SIRTTG组的PWV比WT组低8-17%（P
Advanced age is accompanied by aortic stiffening that is associated with decreased vascular expression of sirtuin-1 (SIRT-1). Interventions that increase SIRT-1 expression also lower age-related aortic stiffness. Therefore, we sought to determine if lifelong SIRT-1 overexpression would attenuate age-related aortic stiffening. Aortic pulse wave velocity (PWV) was assessed from 3-24 months in SIRT-1 transgenic overexpressing (SIRTTG) and wildtype (WT) mice. To determine the role of aortic structural changes on aortic stiffening, histological assessment of aortic wall characteristics was performed. Across the age range (3-24 mo), PWV was 8-17% lower in SIRTTG vs. WT (P