Treating glioblastoma often makes a MES

Treating glioblastoma often makes a MES
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治疗胶质母细胞瘤通常会导致 MES

DOI:
10.1038/s43018-022-00471-1
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发表时间:
2022
期刊:
影响因子:
22.7
通讯作者:
Stead L
Stead L
中科院分区:
医学1区
文献类型:
--
作者:
Stead L

文献摘要

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胶质母细胞瘤(GBM)脑肿瘤细胞表现出明显的表型可塑性,但具体如何使GBM不可避免地抵抗标准治疗尚不清楚。一项新的研究使用了治疗前和治疗后的人类GBM的多水平分子图谱,以单细胞和空间分辨率阐明治疗反应。
Glioblastoma (GBM) brain tumor cells exhibit pronounced phenotypic plasticity, but exactly how this enables GBMs to inevitably resist standard treatment is not known. A new study uses multilevel molecular profiling of pre- and post-treatment human GBMs to shed light on treatment response with single-cell and spatial resolution.