Striation is the characteristic neuritic abnormality in Alzheimer disease.
Striation is the characteristic neuritic abnormality in Alzheimer disease.
复制标题
条纹是阿尔茨海默病的特征性神经炎异常。
DOI：
10.1016/s0006-8993(98)01034-8
复制
发表时间：
1998
期刊：
影响因子：
2.9
通讯作者：
Perry,G
中科院分区：
文献类型：
--
作者：
Velasco,ME;Smith,MA;Siedlak,SL;Nunomura,A;Perry,G
在这项研究中，我们发现阿尔茨海默病的神经纤维，而不是连续的细丝沿着细胞过程，显示出多个中断。它们是节段性的，因此沿着神经突的长度呈现为条纹而不是连续的细丝沿着。神经炎条纹不是切片厚度的伪影，因为大多数异常细丝积聚都非常短。短条纹的优势表明，嗜银颗粒，而不是独特的结构，只是代表一个短的条纹的变体和较长的条纹被任意认为是神经纤维的线程。超微结构检查表明，条纹之间的间隔缺乏细胞骨架。我们认为，神经炎条纹可能会中断微管系统功能性阻断快速神经炎运输，以及发挥作用，在神经元连接的损失。
In this study, we found that neuropil threads of Alzheimer disease, rather than being continuous filaments along cell processes, show multiple interruptions. They are segmental in nature and therefore appear as striations rather than continuous filaments along the length of the neurite. Neuritic striation is not an artifact of section thickness since the majority of abnormal filament accumulations are extremely short. The dominance of short striations demonstrates that argyrophilic grains, rather than being distinct structures, simply represent a short variant of striation and that longer striations are arbitrarily considered neuropil threads. Ultrastructural examination showed that the intervals between striations lack a cytoskeleton. We suggest that neuritic striations may interrupt the microtubule system functionally blocking fast neuritic transport as well as playing a role in loss of neuronal connectivity.