Cell therapy for neurological disorders: Progress towards an embryonic medial ganglionic eminence progenitor-based treatment.
Cell therapy for neurological disorders: Progress towards an embryonic medial ganglionic eminence progenitor-based treatment.
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DOI：
10.3389/fnins.2023.1177678
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发表时间：
2023
影响因子：
4.3
通讯作者：
Baraban, Scott C.
中科院分区：
文献类型：
--
作者：
Righes Marafiga, Joseane;Baraban, Scott C.
抑制性中间神经元的发育、迁移或功能受损是许多基于回路的神经系统疾病（例如癫痫）的关键特征。从治疗的角度来看，这些疾病的对症治疗通常依赖于药物或深部脑刺激方法来全面增强 GABA 介导的抑制作用。针对这些病理回路并可能提供真正的疾病缓解疗法的更有效策略是选择性地将新的抑制性中间神经元添加到这些回路中。其中一种策略是使用胚胎内侧神经节 (MGE) 祖细胞作为独特的中间神经元亚群的来源，已被证明作为细胞移植疗法在各种神经系统疾病的临床前模型中是有效的，特别是在获得性癫痫的小鼠模型中。在这里，我们将讨论这种基于中间神经元的移植疗法在获得性癫痫模型中的演变，重点是 MGE 祖细胞最近适应异种移植到大型哺乳动物中。
Impairment of development, migration, or function of inhibitory interneurons are key features of numerous circuit-based neurological disorders, such as epilepsy. From a therapeutic perspective, symptomatic treatment of these disorders often relies upon drugs or deep brain stimulation approaches to provide a general enhancement of GABA-mediated inhibition. A more effective strategy to target these pathological circuits and potentially provide true disease-modifying therapy, would be to selectively add new inhibitory interneurons into these circuits. One such strategy, using embryonic medial ganglionic (MGE) progenitor cells as a source of a unique sub-population of interneurons, has already proven effective as a cell transplantation therapy in a variety of preclinical models of neurological disorders, especially in mouse models of acquired epilepsy. Here we will discuss the evolution of this interneuron-based transplantation therapy in acquired epilepsy models, with an emphasis on the recent adaptation of MGE progenitor cells for xenotransplantation into larger mammals.
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