Susceptibility to Leishmania major infection in interleukin-4-deficient mice
Susceptibility to Leishmania major infection in interleukin-4-deficient mice
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DOI：
10.1126/science.271.5251.987
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发表时间：
1996-02-16
期刊：
影响因子：
56.9
通讯作者：
Muller, I
中科院分区：
文献类型：
--
作者：
NobenTrauth, N;Kropf, P;Muller, I
白细胞介素-4（IL-4）是一种多效性细胞因子，是免疫系统的主要调节因子，被认为对T辅助细胞2型（T（H）2）应答的发展至关重要。BALB/c小鼠对感染硕大利什曼原虫的易感性与极化T（H）2反应和不能下调IL-4产生有关。通过破坏BALB/c胚胎干细胞中的IL-4基因直接检查IL-4在体内的作用。尽管缺乏IL-4，遗传纯系BALB/c突变小鼠仍然对L.严重感染，没有显示病灶愈合或寄生虫清除的迹象，并且没有转变为T（H）1表型。
Interleukin-4 (IL-4), a pleiotropic cytokine, is a major regulator of the immune system and is considered crucial for the development of T helper cell type 2 (T(H)2) responses. The susceptibility of BALB/c mice to infection with Leishmania major has been associated with a polarized T(H)2 response and an inability to down-modulate IL-4 production. The role of IL-4 in vivo was examined directly by disrupting the IL-4 gene in BALB/c embryonic stem cells. Despite the absence of IL-4, the genetically pure BALB/c mutant mice remained susceptible to L. major infection, Showed no signs of lesion healing or parasite clearance, and did not switch to a T(H)1 phenotype.