Implementation of public health genomics and applications to public health dentistry
Implementation of public health genomics and applications to public health dentistry
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DOI：
10.1111/jphd.12307
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发表时间：
2020-03-01
影响因子：
2.3
通讯作者：
Duquette, Debra
中科院分区：
文献类型：
--
作者：
Duquette, Debra
国家和州的公共卫生基因组学努力有效和负责任地转化基于基因组的知识，以改善人口健康和减少健康差距。在过去的二十年里，公共卫生基因组学的努力利用了评估，政策制定和保证的核心公共卫生功能。目前有少量基因组应用的证据表明，如果在推荐的人群中实施，许多生命可以挽救。随着新的基因检测和技术的急剧增加，包括公共卫生牙科在内的多学科公共卫生基因组学工作变得更加重要。有必要将公共卫生牙科纳入努力，以增加基于证据的基因组检测和服务的使用，以改善健康结果。此外，还利用公共卫生基因组工作来提高对绝大多数基因组测试的有效性、实用性和伦理、法律的和社会影响的证据不足的认识。最近的基因检测政策声明和美国牙科协会的教育资源证明了这一点。在公共卫生基因组学的其他领域也应该考虑这些组织努力，以确保只有有充分证据可供使用的基因检测和预防服务才能在临床和公共卫生领域得到实施。
National and state public health genomics efforts exist to effectively and responsibly translate genome-based knowledge to improve population health and reduce health disparities. Over the past two decades, public health genomics efforts have utilized the core public health functions of assessment, policy development, and assurance. Current evidence for a small number of genomic applications suggests that many lives could be saved if these were implemented in recommended populations. With the drastic increase in new genetic tests and technologies, multidisciplinary public health genomics efforts that should include public health dentistry are of greater importance. There is a need to integrate public health dentistry in efforts to increase use of evidence-based genomic tests and services to improve health outcomes. Additionally, public health genomic efforts also are utilized to promote awareness about the insufficient evidence of the validity, utility and ethical, legal, and social implications for the vast majority of genomic tests. This is demonstrated by a recent genetic testing policy statement and educational resources from the American Dental Association. These organizational efforts should be considered in other realms of public health genomics to ensure that only genetic tests and preventive services with sufficient evidence for use are being implemented in clinical and public health.