Induction of immunoreactive somatomedin C human serum by growth hormone: dose-response relationships and effect on chromatographic profiles.
Induction of immunoreactive somatomedin C human serum by growth hormone: dose-response relationships and effect on chromatographic profiles.
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生长激素诱导免疫反应性生长调节素 C 人血清：剂量反应关系和对色谱图的影响。
DOI：
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发表时间：
1980
影响因子：
5.8
通讯作者：
J. J. Wyk
中科院分区：
文献类型：
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作者：
Kenneth C. Copeland;L. E. Underwood;J. J. Wyk
用敏感、特异的放射免疫分析法测定了30例低血压患者和正常人的生长调节素C（SM-C）的诱导作用。2例低血糖患者分别接受0.1 U人GH（hGH）/kg BW静脉推注，随后连续输注0.01 U hGH/kg-h 12 h。SM-C的最早升高在6-8 h之间可检测到。在对hGH肌肉注射的反应中，低血糖患者在SM-C升高之前延迟8小时，在16-28小时之间达到峰值反应，并在48小时时下降至接近基础水平。血清SM-C对hGH给药反应的延迟表明SM不是以易释放的形式储存的，GH对SM产生的影响可能是通过刺激从头合成。hGH以0.1、0.2、0.4和0.8 U/kg（im）的顺序分级给药引起SM-C反应的阶梯模式。然而，当这些剂量的给药顺序改变时，很明显SM-C反应的幅度被确定。
The induction of somatomedin C (SM-C) was evaluated in 30 hypopituitary patients and in normal subjects using a sensitive, specific RIA for SM-C. Two hypopituitary patients each received an iv bolus of 0.1 U human GH (hGH)⁄kg BW, followed by continuous infusion of 0.01 U hGH⁄kg-h for 12 h. The earliest rise in SM-C was detectable between 6-8 h. In response to the im administration of hGH, hypopituitary patients demonstrated a delay of 8 h before the rise in SM-C, a peak response between 16-28 h, and a fall nearly to basal levels by 48 h. The delay in the serum SM-C response to the administration of hGH suggests that SM is not stored in a readily releasable form and that the effect of GH on SM production may be through the stimulation of de novo synthesis. Graded doses of hGH in a sequence of 0.1, 0.2, 0.4, and 0.8 U/kg (im) elicited a stairstep pattern of SM-C response. When the sequence of administration of these doses was altered, however, it was apparent that the magnitude of the SM-C response was dete...