Bone morphogenetic proteins as regulators of iron metabolism.
Bone morphogenetic proteins as regulators of iron metabolism.
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DOI：
10.1146/annurev-nutr-071813-105646
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发表时间：
2014
影响因子：
8.9
通讯作者：
Fleming RE
中科院分区：
文献类型：
--
作者：
Parrow NL;Fleming RE
骨形态发生蛋白（BMPs）是转化生长因子-β (TGF-β)信号分子超家族的成员。除了蛋白质在胚胎发育、种系规范和细胞分化中的作用外，最近已经证明某些bmp在铁稳态中起核心作用。具体来说，BMP6将肝铁储存与铁调节激素hepcidin的肝细胞表达联系起来。这种调节是通过细胞smad信号分子发生的，并受到BMP共受体血幼蛋白（HJV）的强烈调节。通过BMP/SMAD途径影响hepcidin信号传导的某些基因突变与人类铁代谢障碍有关，如遗传性血色素沉着症和铁难解性缺铁性贫血。有证据表明，除了铁储存外，信号还通过BMP/SMAD途径影响hepcidin的表达。这篇综述综述了BMP/SMAD信号的细节，特别关注其在铁稳态和铁相关疾病中的作用。
Bone morphogenetic proteins (BMPs) are members of the transforming growth factor-beta (TGF-β) superfamily of signaling molecules. In addition to protean roles in embryonic development, germ-line specification, and cellular differentiation, a central role in iron homeostasis has recently been demonstrated for certain BMPs. Specifically, BMP6 serves to relate hepatic iron stores to the hepatocellular expression of the iron-regulatory hormone hepcidin. This regulation occurs via cellular SMAD-signaling molecules and is strongly modulated by the BMP coreceptor hemojuvelin (HJV). Mutations in certain genes influencing signaling to hepcidin via the BMP/SMAD pathway are associated with human disorders of iron metabolism, such as hereditary hemochromatosis and iron-refractory iron-deficiency anemia. Evidence suggests that signals in addition to iron stores influence hepcidin expression via the BMP/SMAD pathway. This review summarizes the details of BMP/SMAD signaling, with a particular focus on its role in iron homeostasis and iron-related diseases.
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影响因子：
29.4
作者：
Corradini E;Schmidt PJ;Meynard D;Garuti C;Montosi G;Chen S;Vukicevic S;Pietrangelo A;Lin HY;Babitt JL
通讯作者：
Babitt JL
影响因子：
15.9
作者：
Babitt, Jodie L.;Huang, Franklin W.;Lin, Herbert Y.
通讯作者：
Lin, Herbert Y.
影响因子：
4.8
作者：
Chung, Bomee;Verdier, Frederique;Vaulont, Sophie
通讯作者：
Vaulont, Sophie
影响因子：
15.9
作者：
Castoldi, Mirco;Spasic, Maja Vujic;Muckenthaler, Martina U.
通讯作者：
Muckenthaler, Martina U.
DOI：
10.1002/hep.23106
发表时间：
2009-07-01
期刊：
Hepatology (Baltimore, Md.)
影响因子：
--
作者：
Anderson, Gregory J
通讯作者：
Anderson, Gregory J