T-type Ca2+ channels in vascular smooth muscle:: Multiple functions
T-type Ca2+ channels in vascular smooth muscle:: Multiple functions
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DOI：
10.1016/j.ceca.2006.04.026
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发表时间：
2006-08-01
期刊：
影响因子：
4
通讯作者：
Cribbs, Leanne L.
中科院分区：
文献类型：
--
作者：
Cribbs, Leanne L.
血管平滑肌是血管壁的主要组成部分，其许多功能取决于血管的类型和位置、发育或病理状态以及环境和化学因素。血管平滑肌细胞 (VSMC) 使用钙作为具有多种功能的信号分子。钙信号通路的一个重要组成部分是细胞外钙通过电压门控 Ca2+ 通道进入，在血管平滑肌细胞 (VSMC) 中，该通道主要有两种类型：高电压激活 (HVA) L 型通道和低电压激活 (LVA) T 型通道。 L 型通道的主要功能是调节 Ca2+ 进入收缩，但人们普遍认为 T 型 Ca2+ 通道对动脉血管收缩没有显着贡献，但肾脏微循环可能除外。 T 型 Ca2+ 通道也存在于一些表现出自发收缩活动的静脉中，它们可能会产生起搏器活动。 T 型 Ca2+ 通道表达也与 VSMC 的正常和病理性增殖相关，通常受到针对损伤或损伤的外部信号的刺激。 T 型通道的表达与细胞周期的 G1 和 S 期相关，这一时期对于细胞生长、细胞周期进展和最终细胞分裂所需的基因表达信号传导非常重要。为了更好地了解 VSM 中的 T 型 Ca2+ 通道功能，有必要开发专门针对此类 Ca2+ 通道及其单个成员的新方法。 (c) 2006 Elsevier Ltd。保留所有权利。
Vascular smooth muscle is a major constituent of the blood vessel wall, and its many functions depend on type and location of the vessel, developmental or pathological state, and environmental and chemical factors. Vascular smooth muscle cells (VSMCs) use calcium as a signal molecule for multiple functions. An important component of calcium signaling pathways is the entry of extracellular calcium via voltage-gated Ca2+ channels, which in vascular smooth muscle cells (VSMCs) are of two main types, the high voltage-activated (HVA) L-type and low voltaae-activated (LVA) T-type channels. Whereas L-type channels function primarily to regulate Ca2+, entry for contraction, it is generally accepted that T-type Ca2+ channels do not contribute significantly to arterial vasoconstriction, with the possible exception of the renal microcirculation. T-type Ca2+ channels are also present in some veins that display spontaneous contractile activity, where they likely generate pacemaker activity. T-type Ca2+ channel expression has also been associated with normal and pathological proliferation of VSMCs, often stimulated by external cues in response to insult or injury. Expression of T-type channels has been linked to the G1 and S phases of the cell cycle, a period important for the signaling of gene expression necessary for cell growth, progression of the cell cycle and ultimately cell division. To better understand T-type Ca2+ channel functions in VSM, it will be necessary to develop new approaches that are specifically targeted to this class of Ca2+ channels and its individual members. (c) 2006 Elsevier Ltd. All fights reserved.