Fabrication of bioactive glass particles composite porous fibers by combination of electrospinning and phase separation
Fabrication of bioactive glass particles composite porous fibers by combination of electrospinning and phase separation
复制标题
静电纺丝与相分离相结合制备生物活性玻璃颗粒复合多孔纤维
DOI：
10.1016/j.matlet.2019.03.143
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发表时间：
2019-08
影响因子：
3
通讯作者：
Chen Xiaofeng
中科院分区：
文献类型：
--
作者：
Xie Weihan;Fu Xiaoling;Wang Yu Dong;Wang Gang;Chen Xiaofeng
本研究采用相分离技术结合静电纺丝技术制备了一种多孔聚己内酯（PCL）生物活性玻璃（BG）支架。氯仿（CF）和二甲基甲酰胺（DMF）被用作良溶剂，而二甲基亚砜（DMSO）被用作不良溶剂，以在纤维表面上产生孔。研究了PCL浓度、DMSO用量和BG粒子用量对静电纺丝纤维表面形貌的影响。通过在具有90%v/v的良/差溶剂比的溶液中使用12%w/v的PCL成功地获得具有均匀分布的孔和均匀直径的纤维支架。在静电纺丝溶液中添加BG颗粒（<8%w/v）不会导致多孔纤维的任何变形。复合BG颗粒的多孔纤维支架有望成为一种新型的软组织工程支架材料。
In the present study, a porous electrospun polycaprolactone (PCL) scaffold incorporated with bioactive glass (BG) particles was fabricated by combining phase separation with electrospinning. Chloroform (CF) and dimethyl formamide (DMF) were used as good solvents, while dimethyl sulfoxide (DMSO) was used as a poor solvent to generate pores on the fiber surface. The effects of PCL concentration, DMSO amount and BG particles dosage on the surface morphology of electrospun fibers were investigated, respectively. Fibrous scaffolds with well-distributed pores and uniform diameter were successfully obtained by using 12% w/v PCL in solution with good/poor solvent ratios at 90% v/v. The addition of BG particles (< 8% w/v) in electrospun solution did not lead to any deformation of the porous fibers. The porous fibrous scaffolds incorporated with BG particles may be a promising scaffolds for soft tissue engineering.
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