INHIBITION OF POTENTIALLY PATHOGENIC YEASTLIKE FUNGI BY CLOTRIMAZOLE IN COMBINATION WITH 5-FLUOROCYTOSINE OR AMPHOTERICIN-B
INHIBITION OF POTENTIALLY PATHOGENIC YEASTLIKE FUNGI BY CLOTRIMAZOLE IN COMBINATION WITH 5-FLUOROCYTOSINE OR AMPHOTERICIN-B
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DOI：
10.1128/aac.9.6.863
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发表时间：
1976-01-01
影响因子：
4.9
通讯作者：
STEELE, NM
中科院分区：
文献类型：
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作者：
BEGGS, WH;SAROSI, GA;STEELE, NM
克霉唑（CTM）在治疗系统性真菌病方面的应用前景令人怀疑。为了评估CTM在联合用药方案中的潜力，在合成液体培养基中测试了CTM与5-氟胞嘧啶（5-FC）或阿替霉素B（AMB）一起对抗白色念珠菌、热带念珠菌和光滑球拟酵母菌的抗真菌作用。在48小时孵育期内监测活菌计数。弱抑制浓度的CTM与单独产生短暂抗真菌作用的5-FC或AMB水平组合进行测试，随后快速恢复增殖能力。研究的每种微生物的结果相似。在24和48小时之间，当单独含有5-FC或AMB的培养物处于恢复期时，CTM加5-FC和CTM加AMB继续显著抑制细胞增殖。这表明，弱抑制浓度的CTM可以与5-FC或AMB一起作用，产生比单独使用后两种药物中的任何一种更大的抗真菌作用。
Clotrimazole (CTM) has a doubtful future with respect to use in treatment of the systemic mycoses. To assess the potential of CTM in combined drug regimens, antifungal effects of CTM together with 5-fluorocytosine (5-FC) or amphotericin B (AMB) were tested in a synthetic liquid medium againstCandida albicans, Candida tropicalis, andTorulopsis glabrata. Viable counts were monitored over a 48-h incubation period. Weak inhibitory concentrations of CTM were tested in combination with levels of 5-FC or AMB that alone produced transient antifungal effects followed by rapid recovery of proliferative capacity. Results were similar for each of the organisms studied. Between 24 and 48 h, when cultures containing 5-FC or AMB alone were in the recovery phase, CTM plus 5-FC and CTM plus AMB continued to markedly suppress cell multiplication. It would appear that weak inhibitory concentrations of CTM can act together with 5-FC or AMB to produce antifungal effects greater than that obtained with either of the latter two drugs alone.