γδ T cells play an essential role in several forms of tolerance
γδ T cells play an essential role in several forms of tolerance
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DOI：
10.1385/ir:29:1-3:093
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发表时间：
2004-01-01
影响因子：
4.4
通讯作者：
McKenna, KC
中科院分区：
文献类型：
--
作者：
Kapp, JA;Kapp, LM;McKenna, KC
γ - T细胞于20世纪80年代中期被发现，但人们对它们识别的抗原及其介导的生物学功能知之甚少。尽管γ - T细胞具有增强对某些感染的免疫力和杀死某些肿瘤细胞的能力，但它们通常不是抗体反应、移植物排斥反应或自身免疫性疾病发展所必需的。然而，γ - T细胞在感染引起的炎症部位聚集。肿瘤生长和自身免疫病变，它们已经被证明可以减少炎症反应和组织损伤。在这篇综述中，我们总结了γ - T细胞在诱导各种形式的耐受性中发挥重要作用的证据。
gammadelta T cells were discovered in the mid-1980s, but the antigens they recognize and the biological functions they mediate are poorly understood. Although gammadelta T cells have the capacity to augment immunity to certain infections and kill certain tumor cells, they are generally not required for development of antibody responses, for graft rejection, or for development of autoimmune diseases. Nevertheless, gammadelta T cells accumulate at sites of inflammation induced by infection. tumor growth, and autoimmune lesions, where they have been shown to reduce the inflammatory reaction and tissue damage. In this review, we summarize the evidence that gammadelta T cells play an important role in the induction of various forms of tolerance.