Urinary Emmprin, matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 as potential biomarkers in children with ureteropelvic junction narrowing on conservative treatment
Urinary Emmprin, matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 as potential biomarkers in children with ureteropelvic junction narrowing on conservative treatment
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DOI：
10.1111/nep.12371
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发表时间：
2015-03
期刊：
影响因子：
2.5
通讯作者：
Fengyan Tian;Chaohui Gu;Zhanzheng Zhao;Luping Li;Shan Lu;Zhenzhen Li
中科院分区：
文献类型：
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作者：
Fengyan Tian;Chaohui Gu;Zhanzheng Zhao;Luping Li;Shan Lu;Zhenzhen Li
先天性梗阻性肾病的快速诊断和治疗对幼儿延缓肾脏损伤具有重要意义。本研究旨在探讨尿液细胞外基质金属蛋白酶诱导物(Emmprin)、基质金属蛋白酶9(MMP9)和金属蛋白酶组织抑制因子1(TIMP 1)在输尿管肾盂连接部(UPJ)狭窄保守治疗中的作用。
Rapid diagnosis and initiation of the treatment on congenital obstructive nephropathy are important for young children to slow down renal injury. The aim of our study was to investigate the role of urinary extracellular matrix metalloproteinase inducer (Emmprin), matrix metalloproteinase 9 (MMP‐9) and tissue inhibitor of metalloproteinase 1 (TIMP‐1) in the long‐term follow‐up of children with ureteropelvic junction (UPJ) narrowing on conservative treatment.