Development of brushite particles synthesized in the presence of acidic monomers for dental applications
Development of brushite particles synthesized in the presence of acidic monomers for dental applications
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DOI：
10.1016/j.msec.2020.111178
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发表时间：
2020-11-01
影响因子：
7.9
通讯作者：
Braga, Roberto R.
中科院分区：
文献类型：
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作者：
Chiari, Marina D. S.;Rodrigues, Marcela C.;Braga, Roberto R.
目的：在酸性单体存在下合成透钙磷石颗粒并对其进行表征（丙烯酸/AA、柠檬酸/CA和甲基丙烯酰氧基乙基磷酸盐/MOEP）的复合材料中，并评估这些颗粒对实验复合材料的转化度（DC）、弯曲强度/模量（FS/FM）和离子释放的影响。通过与添加到磷酸盐前体溶液中的单体共沉淀合成颗粒，并对单体含量、尺寸和形态进行表征。复合材料含有20体积%透钙磷石和40体积%的增强玻璃进行了测试DC，FS和FM（24小时和60天后，在水中），和60天的离子释放。对数据进行ANOVA/Tukey检验（DC）或Kruskal-Wallis/Dunn检验（FS和FM，α：5%）。颗粒上的镁含量低（0.1- 1.4质量%）。复合材料呈现类似的DC。对于FS/24 h，仅含有DCPD_AA的复合材料在统计学上类似于含有60体积%增强玻璃的复合材料（不含透钙磷石，“对照”）。60天后，所有含勃氏石的材料显示相似的FS，统计学上低于对照复合材料（p < 0.01）。含有DCPD_AA、DCPD_MOEP或DCPD_U（“未改性”）的复合材料显示出统计学上相似的FM/24 h，高于对照复合材料。长时间浸泡后，除DCPD_AA外，所有复合材料与对照复合材料相似。累积离子释放范围为21 ppm至28 ppm（钙）和9 ppm至17 ppm（磷酸盐）。仅检测到含有DCPD_MOEP.Significance的复合物在15和60天之间的离子释放的统计学显著减少：酸性单体添加到合成影响透钙磷石颗粒形态。在水中储存60天后，所有含水镁石的复合材料的复合强度相似。离子释放持续60天，它不受颗粒形态的影响。
Objectives: To synthesize and characterize brushite particles in the presence of acidic monomers (acrylic acid/AA, citric acid/CA, and methacryloyloxyethyl phosphate/MOEP) and evaluate the effect of these particles on degree of conversion (DC), flexural strength/modulus (FS/FM) and ion release of experimental composites.Methods: Particles were synthesized by co-precipitation with monomers added to the phosphate precursor solution and characterized for monomer content, size and morphology. Composites containing 20 vol% brushite and 40 vol% reinforcing glass were tested for DC, FS and FM (after 24 h and 60 d in water), and 60-day ion release. Data were subjected to ANOVA/Tukey tests (DC) or Kruskal-Wallis/Dunn tests (FS and FM, alpha: 5%).Results: The presence of acidic monomers affected particle morphology. Monomer content on the particles was low (0.1-1.4% by mass). Composites presented similar DC. For FS/24 h, only the composite containing DCPD_AA was statistically similar to the composite containing 60 vol% of reinforcing glass (without brushite, "control"). After 60 days, all brushite-containing materials showed similar FS, statistically lower than the control composite (p < 0.01). Composites containing DCPD_AA, DCPD_MOEP or DCPD_U ("unmodified") showed statistically similar FM/24 h, higher than the control composite. After prolonged immersion, all composites were similar to the control composite, except DCPD_AA. Cumulative ion release ranged from 21 ppm to 28 ppm (calcium) and 9 ppm to 17 ppm (phosphate). Statistically significant reductions in ion release between 15 and 60 days were detected only for the composite containing DCPD_MOEP.Significance: Acidic monomers added to the synthesis affected brushite particle morphology. After 60-day storage in water, composite strength was similar among all brushite-containing composites. Ion release was sustained for 60 days and it was not affected by particle morphology.