Immunoregulation in hypersensitivity pneumonitis: phenotypic and functional studies of bronchoalveolar lavage lymphocytes.
Immunoregulation in hypersensitivity pneumonitis: phenotypic and functional studies of bronchoalveolar lavage lymphocytes.
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过敏性肺炎的免疫调节：支气管肺泡灌洗淋巴细胞的表型和功能研究。
DOI：
10.1164/arrd.1984.130.5.766
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Fink,JN
中科院分区：
文献类型：
--
作者：
Keller,RH;Swartz,S;Schlueter,DP;Bar-Sela,S;Fink,JN
我们研究了免疫表型和功能的支气管肺泡淋巴细胞分离的4鸽子饲养者谁开发的过敏性肺炎的症状暴露于鸽子，和6个无症状，但同样暴露的个人。与无症状相比，在有症状的繁殖者中发现了类似数量的支气管肺泡淋巴细胞，并且两组中T11、T4和T8承载细胞的百分比以及T4/T8比率相似。尽管有这些相似之处，但各组的功能活动明显不同。与无症状的育种者相比，有症状的育种者的支气管肺泡淋巴细胞对植物血凝素和鸽子血清刺激的囊胚形成活性显着增加（p < 0.001）。此外，富集支气管肺泡T细胞抑制自体预孵育的外周血淋巴细胞的反应，植物血凝素和鸽子血清中的无症状相比，有症状的育种。这些研究表明，免疫调节T细胞亚群的表型和功能之间的差异，在鸽育种家的疾病支气管肺泡灌洗液淋巴细胞，并支持功能性免疫调节失衡的过敏性肺炎的发病机制中的作用。
We examined the immunologic phenotype and function of bronchoalveolar lymphocytes isolated from 4 pigeon breeders who developed symptoms of hypersensitivity pneumonitis on exposure to pigeons, and 6 asymptomatic but equally exposed individuals. Similar numbers of bronchoalveolar lymphocytes were found in symptomatic breeders compared with the asymptomatic, and the percent of T11, T4, and T8 bearing cells as well as the T4/T8 ratios were similar in both groups. Despite these similarities, the groups had significantly different functional activity. Bronchoalveolar lymphocytes from symptomatic breeders demonstrated a marked (p < 0.001) increase in blastogenic activity to both phytohemagglutinin and pigeon serum stimulation when compared with asymptomatic breeders. In addition, enriched bronchoalveolar T-cells suppressed the response of autologous preincubated peripheral blood lymphocytes to both phytohemagglutinin and pigeon serum in the asymptomatic compared with the symptomatic breeders. These studies suggest a discrepancy between the phenotype and function of immunoregulatory T-cell subsets in bronchoalveolar lavage lymphocytes in pigeon breeder's disease, and support a role for functional immunoregulatory imbalances in the pathogenesis of hypersensitivity pneumonitis.