Pubertal timing is an independent predictor of central adiposity in young adult males -: The Gothenburg Osteoporosis and Obesity Determinants study
Pubertal timing is an independent predictor of central adiposity in young adult males -: The Gothenburg Osteoporosis and Obesity Determinants study
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DOI：
10.2337/db06-0192
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发表时间：
2006-11-01
期刊：
影响因子：
7.7
通讯作者：
Ohlsson, Claes
中科院分区：
文献类型：
--
作者：
Kindblom, Jenny M.;Lorentzon, Mattias;Ohlsson, Claes
青春期和青春期时间的正常变化在男性肥胖发展中的作用尚不清楚。本研究的目的是调查青春期时间和青春期前BMI（kg/m2）对年轻成人BMI和脂肪量分布的影响。检索了参与基于人群的哥德堡骨质疏松和肥胖决定因素研究的男性从出生到18-20岁的详细生长图表。对5 - 79名受试者的身高峰值速度（PHV）和10岁时的BMI进行了估计，并将PHV用作青春期时间的评估。在18.9 ± 0.5岁时，使用双能X线吸收测定法和外周以及腹部计算机断层扫描分析脂肪量特征和分布。我们证明，PHV时的年龄是年轻成人BMI和全身脂肪量的独立负预测因子。有趣的是，PHV时的年龄是中心脂肪量的独立负预测因子，而不是外周脂肪量。相比之下，10岁时的BMI可以预测中心和外周皮下脂肪量。总之，我们表明，青春期早期发病特别预测中央脂肪质量分布，而主要是皮下肥胖表型强烈预测青春期前BMI高。
The role of puberty and normal variations in pubertal timing for the development of obesity in men is unclear. The aim of the current study was to investigate the impact of pubertal timing and prepubertal BMI (kg/m(2)) for young adult BMI and fat mass distribution. Detailed growth charts from birth to age 18-20 years were retrieved for the men participating in the population-based Gothenburg Osteoporosis and Obesity Determinants study. Age at peak height velocity (PHV) and BMI at age 10 years were estimated for 5 79 subjects, and PHV was used as an assessment of pubertal timing. The fat mass characterization and distribution were analyzed using dual X-ray absorptiometry and peripheral as well as abdominal computed tomography at age 18.9 +/- 0.5 years. We demonstrate that age at PHV is an independent negative predictor of young adult BMI and whole-body fat mass. Interestingly, age at PHV is an independent negative predictor of central, but not peripheral, fat mass. In contrast, BMI at 10 years of age predicts both central and peripheral subcutaneous fat mass. In conclusion, we demonstrate that early pubertal onset specifically predicts a central fat mass distribution, while a predominantly subcutaneous obese phenotype is strongly predicted by a high prepubertal BMI.