Experimental studies of acute renal failure. I. The protective effect of mannitol.
Experimental studies of acute renal failure. I. The protective effect of mannitol.
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急性肾衰竭的实验研究。
DOI：
10.1016/s0022-5347(17)64488-4
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发表时间：
1963
期刊：
影响因子：
--
通讯作者：
C. B. Mueller
中科院分区：
文献类型：
--
作者：
William L. Parry;J. A. Schaefer;C. B. Mueller
方法准备动物。在这项研究中，雄性 Sprague-Dawley 大鼠，体重 150 至 200 克。每个都被使用了。两只老鼠共用一个笼子，并以普瑞纳老鼠颗粒作为标准饮食。实验前 3 天随意摄入马肉、燕麦和水，平均体重增加 12%。此后，在注射色素之前的 24 小时内，老鼠不再吃马肉和水，只吃燕麦，平均体重减轻了 7%。一般而言，10～18只大鼠为一组同时注射，任意组内的死亡或存活结果用于组间比较。一些实验情况重复了几次，报告的结果显示了所有可比组中动物的总和。
METHODSPreparation of animals. In this study, male Sprague-Dawley rats, weighing 150 to 200 gm. each were used. Two rats shared a cage and ate Purina rat pellets as a standard diet. Diets of horsemeat, oats and water were given ad lib for 3 days prior to an experiment with an average weight gain of 12 per cent. Following this, the horsemeat and water were eliminated and the rats ate only oats for 24 hours prior to pigment injection with an average weight loss of 7 per cent. Generally speaking, groups of 10 to 18 rats were injected simultaneously and the results of deatb or survival within any groups were used for comparison between groups. Some experimental situations were repeated several times and the reported results show the sum of animals in all of the comparable groups.