Vomeronasal mechanisms of mate recognition in mice
Vomeronasal mechanisms of mate recognition in mice
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DOI：
10.1093/chemse/bjh157
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发表时间：
2005-01-01
期刊：
影响因子：
3.5
通讯作者：
Binns, EK
中科院分区：
文献类型：
--
作者：
Brennan, PA;Binns, EK
动物区分个体同种的能力影响它们行为的许多方面，包括配偶的选择、领土标记和母子互动。在啮齿类动物中，关于个体的信息是通过尿液和身体分泌物中的化学线索传达的。因此，可以训练小鼠辨别仅在主要组织相容性复合体（MHC）基因上不同的同类小鼠的尿液气味。这种能力可能是基于尿挥发物谱中与MHC相关的差异（Singer等人，1997），其由主嗅觉系统感知并在主嗅球中的大量神经元中产生统计学上不同的活动模式（Schaefer等人，2002年）。相比之下，雄性小鼠的尿液标记行为的个体识别取决于主要尿蛋白的谱而不是MHC类型（Hurst等人，2001），表明小鼠在不同的行为环境中使用不同的化学信号来传递个体身份。此外，关于小鼠个体身份的信息可以通过主要的嗅觉系统和犁鼻系统来传达。而主要的嗅觉系统是适应学习和歧视的空气中挥发物的配置文件中的小差异，犁鼻系统的响应范围更有限的非挥发性刺激后采取的直接接触。此外，犁鼻系统中个体身份的表征似乎与主嗅觉系统中的个体身份的表征不同，因为副嗅球（AOB）中的个体神经元高度选择性地响应麻醉同种的菌株身份（Luo等人，2003年）。
The ability of animals to distinguish individual con-specifics influences many aspects of their behaviour, including choice of mate, territorial marking and mother-offspring interactions. In rodents, information about individuality is conveyed by chemical cues in their urine and body secretions. Hence, mice can be trained to discriminate the urine odour of congenic mice that differ only in genes of their major histocompatibility complex (MHC). This ability is likely to be based on MHC-related differences in the profile of urinary volatiles (Singer et al., 1997), which are sensed by the main olfactory system and generate statistically different patterns of activity across large populations of neurons in the main olfactory bulb (Schaefer et al., 2002). In contrast, individual recognition underlying urine countermarking behaviour of male mice depends on the profile of major urinary proteins rather than MHC type (Hurst et al., 2001), suggesting that mice use different chemosignals for signalling individual identity in different behavioural contexts. Furthermore, information about the individual identity of mice can be conveyed by both the main olfactory and vomeronasal systems. Whereas the main olfactory system is adapted to learn and discriminate small differences in the profile of airborne volatiles, the vomeronasal system responds to a more limited range of non-volatile stimuli taken up following direct contact. Moreover, the representation of individual identity in vomeronasal system appears to differ from that in the main olfactory system, as individual neurons in the accessory olfactory bulb (AOB), respond highly selectively to the strain identity of anaesthetized conspecifics (Luo et al., 2003).