Tumor Perfusion-Related Parameter of Diffusion-Weighted Magnetic Resonance Imaging: Correlation with Histological Microvessel Density
Tumor Perfusion-Related Parameter of Diffusion-Weighted Magnetic Resonance Imaging: Correlation with Histological Microvessel Density
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DOI：
10.1002/mrm.24810
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发表时间：
2014-04-01
影响因子：
3.3
通讯作者：
Choi, Byoung Wook
中科院分区：
文献类型：
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作者：
Lee, Hye-Jeong;Rha, Sun Young;Choi, Byoung Wook
目的利用多个b值对磁共振弥散加权成像(DWI)进行双指数分析，得到体素内非相干运动(IVIM)参数。方法对25只接种HT29结直肠癌细胞的裸鼠进行多倍b值(0、50、100、300、500、700、1000 S/mm(2))的弥散加权成像。采用双指数分析方法计算组织扩散率(D-t)、伪扩散系数(D-p)和血流灌注分数(f(P))，并将这些参数与MVD进行相关分析。CD31染色检测微血管密度。结果D-t=0.980.06x10(-3)mm(2)/S，r=0.139(P=0.508)，D-p=23.70+/-7.94x10(-3)mm(2)/S，r=0.782(P<；0.001)，f(P)=15.58+/-5.7%，r=0.749(P<；0.001)。D-p和f(P)与MVD有显著相关性，而D-t与MVD无相关性。结论弥散加权成像的IVIM参数D-p和f(P)可用于无创性评价MVD。Magn Reson Med 71：1554-1558,2014。(C)2013年威利期刊公司。
PurposeWe obtained intravoxel incoherent motion (IVIM) parameters through biexponential analysis on diffusion-weighted MR imaging (DWI) using multiple b values. Correlation was evaluated between these parameters and histological microvessel density (MVD) for the possibility of noninvasive evaluation of MVD with DWI.MethodsTwenty-five nude mice with the HT29 colorectal cancer cells implanted were analyzed after undergoing DWI with multiple b values (0, 50, 100, 300, 500, 700, and 1000 s/mm(2)). Tissue diffusivity (D-t), pseudo-diffusion coefficient (D-p), and perfusion fraction (f(p)) were calculated using a biexponential analysis, and these parameters were correlated with MVD. The MVD was determined with the CD31 stain. For statistical analysis, Spearman's rank correlation was applied.ResultsThe mean value and correlation coefficient with MVD for each IVIM parameter were as follows: D-t=0.980.06x10(-3) mm(2)/s with r=0.139 (P=0.508); D-p=23.70 +/- 7.94x10(-3) mm(2)/s with r=0.782 (P < 0.001); and f(p)=15.58 +/- 5.7% with r=0.749 (P < 0.001). D-p and f(p) showed significant correlation with MVD, but D-t did not.ConclusionThe IVIM parameters, D-p and f(p), on DWI might be used in the noninvasive evaluation of MVD. Magn Reson Med 71:1554-1558, 2014. (c) 2013 Wiley Periodicals, Inc.