Profiling cellular and inflammatory changes in the airway wall of mild to moderate COPD
Profiling cellular and inflammatory changes in the airway wall of mild to moderate COPD
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DOI：
10.1111/resp.13021
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发表时间：
2017-08-01
期刊：
影响因子：
6.9
通讯作者：
Sohal, Sukhwinder S.
中科院分区：
文献类型：
--
作者：
Eapen, Mathew S.;McAlinden, Kielan;Sohal, Sukhwinder S.
Background and objectiveThe objective of this study was to enumerate total cells and the number of inflammatory cell differentials in large airways (LAs) versus small airways (SAs) of mild-moderate COPD, and against appropriate controls.MethodsFor LA, we used endobronchial biopsies and for SA resected lung tissues. Immunostaining was enumerated (cells per mm(2)) for macrophages, neutrophils, CD4 and CD8 T cells in the lamina propria (LP) up to 150 mu M deep for LA and full wall thickness for SA.ResultsWe confirmed hypocellularity in the LA and in the SA wall in smokers and COPD (P
