Effect of gonadotropin-releasing hormone on prolactin levels in males unrelated to stress or behavioral changes.
Effect of gonadotropin-releasing hormone on prolactin levels in males unrelated to stress or behavioral changes.
复制标题
促性腺激素释放激素对男性催乳素水平的影响与压力或行为变化无关。
DOI：
10.1002/j.1939-4640.1987.tb03305.x
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发表时间：
1987
影响因子：
--
通讯作者：
Schiff,I
中科院分区：
文献类型：
--
作者：
Phipps,WR;Lukas,SE;Mendelson,JH;Schiff,I
对5名正常男性进行500 μg促性腺激素释放激素（GnRH）或安慰剂双盲静脉给药后，评估激素水平、生理参数、脑电图（EEG）活动和使用非语言仪器设备记录的主观感受变化。在GnRH给药30分钟内，催乳素（PRL）水平从基线8.5 ± 0.9 ng/ml上升了4.3 ± 1.2 ng/ml（平均值± SEM）（总体增加P < 0.005 vs基线，P< 0.001 vs安慰剂）;最大刺激值的平均值为16.7 ± 2.3 ng/ml。PRL绝对值升高与促黄体生成素（LH）（r=0.97）和促卵泡激素（FSH）（r=0.89）升高显著相关。GnRH未引起生理参数或EEG活动的变化，也未发现任何行为反应，GnRH后PRL的增加与实验应激或GnRH的行为效应无关。
Hormone levels, physiologic parameters, electroencephalographic (EEG) activity, and changes in subjective feelings recorded using a nonverbal instrumental device were assessed following the double‐blind intravenous administration of 500 μg of gonadotropin‐releasing hormone (GnRH) or placebo to five normal males. Within 30 minutes of GnRH administration, prolactin (PRL) levels had risen by 4.3 ± 1.2 ng/ml (mean ± SEM) from a baseline of 8.5 ± 0.9 ng/ml (overall increaseP< 0.005 vs. baseline,P< 0.001 vs. placebo); maximally stimulated values had a mean of 16.7 ± 2.3 ng/ml. The PRL elevations measured in absolute terms significantly correlated with increases in luteinizing hormone (LH) (r=0.97) and follicle stimulating hormone (FSH),(r=0.89). No changes in physiologic parameters or EEG activity occurred in response to GnRH, nor were any behavioral responses found. The increase in PRL following GnRH was specifically shown to be unrelated to experimental stress or the behavioral effects of GnRH.