New antiplasmodial indole alkaloids from Hunteria zeylanica
New antiplasmodial indole alkaloids from Hunteria zeylanica
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DOI：
10.1016/j.bmcl.2011.03.104
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发表时间：
2011-06-01
影响因子：
2.7
通讯作者：
Morita, Hiroshi
中科院分区：
文献类型：
--
作者：
Nugroho, Alfarius E.;Sugai, Masatomo;Morita, Hiroshi
从白桦树皮中分离到两种新的吲哚类生物碱：双烟碱碱D(1)和烟碱碱a(2)。通过核磁共振和CD谱等光谱数据对其结构进行了分析。双烟碱酯和烟碱酯A对恶性疟原虫3D7表现出较强的抗疟原虫活性。(C) 2011 Elsevier Ltd.版权所有。
Two new indole alkaloids, bisnicalaterine D (1), consisting of an eburnane and a corynanthe type of skeletons, and nicalaterine A (2) were isolated from the bark of Hunteria zeylanica. Their structures were elucidated by various spectroscopic data such as NMR and CD spectra. A series of bisnicalaterines and nicalaterine A showed potent antiplasmodial activity against Plasmodium falciparum 3D7. (C) 2011 Elsevier Ltd. All rights reserved.