Hippocampal-prefrontal long-term potentiation-like plasticity with transcranial direct current stimulation in rats
Hippocampal-prefrontal long-term potentiation-like plasticity with transcranial direct current stimulation in rats
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DOI：
10.1016/j.nlm.2023.107750
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发表时间：
2023-04
影响因子：
2.7
通讯作者：
Y. Watanabe;Shinnosuke Dezawa;Hiroyuki Takei;K. Nagasaka;I. Takashima
中科院分区：
文献类型：
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作者：
Y. Watanabe;Shinnosuke Dezawa;Hiroyuki Takei;K. Nagasaka;I. Takashima
经颅直流电刺激作为一种新的改善认知和运动功能的治疗方法已被探索。然而，tDCs调节大脑功能，特别是认知和记忆功能的神经机制还不是很清楚。在本研究中，我们评估了tdcs是否能促进大鼠海马区和前额叶皮质之间的神经元可塑性。这一点很重要，因为海马体-前额叶通路是认知和记忆功能的关键通路，与各种精神和神经退行性疾病有关。具体地说，通过测量内侧前额叶皮质对电刺激大鼠海马区CA1区的反应，研究了阴阳极tdcs对大鼠内侧前额叶皮质的影响。在阳极tdcs状态下，诱发的前额叶反应较tdcs前状态下有所增强。然而，诱发的前额叶反应在阴极tdcs后没有显示任何明显的变化。此外，正极tdcs后前额叶反应的可塑性改变仅在tdcs期间持续刺激海马区时才发生。未激活海马区的阳极TDCs变化很小或无变化。这些结果表明，将前额叶皮质的负极TDCs与激活海马相结合，可在海马-前额叶通路中诱导类似长时程增强(LTP)的可塑性。这种类似LTP的可塑性可以促进海马体和前额叶皮质之间顺利的信息传递，并可能导致认知和记忆功能的改善。
Transcranial direct current stimulation (tDCS) has been explored as a new treatment method for improving cognitive and motor functions. However, the neuronal mechanisms of tDCS in modulating brain functions, especially cognitive and memory functions, are not well understood. In the present study, we assessed whether tDCS could promote neuronal plasticity between the hippocampus and prefrontal cortex in rats. This is important because the hippocampus-prefrontal pathway is a key pathway in cognitive and memory functions and is involved in various psychiatric and neurodegenerative disorders. Specifically, the effect of anodal or cathodal tDCS on the medial prefrontal cortex was investigated in rats by measuring the medial prefrontal cortex response to electrical stimulation applied to the CA1 region of the hippocampus. Following anodal tDCS, the evoked prefrontal response was potentiated compared to that in the pre-tDCS condition. However, the evoked prefrontal response did not show any significant changes following cathodal tDCS. Furthermore, the plastic change of the prefrontal response following anodal tDCS was only induced when hippocampal stimulation was continuously applied during tDCS. Anodal tDCS without hippocampal activation showed little or no changes. These results indicate that combining anodal tDCS of the prefrontal cortex with hippocampal activation induces long-term potentiation (LTP)-like plasticity in the hippocampus-prefrontal pathway. This LTP-like plasticity can facilitate smooth information transmission between the hippocampus and the prefrontal cortex and may lead to improvements in cognitive and memory function.