Activation-induced deaminase: controversies and open questions
Activation-induced deaminase: controversies and open questions
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DOI：
10.1016/j.it.2004.12.004
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发表时间：
2005-02-01
影响因子：
16.8
通讯作者：
Nussenzweig, MC
中科院分区：
文献类型：
--
作者：
Barreto, VM;Ramiro, AR;Nussenzweig, MC
激活诱导脱氨酶（AID）在三个不同的反应中是必需的，这些反应对抗体库的多样化至关重要；它们分别是体细胞超突变（SHM）、类开关重组（CSR）和基因转换（GC）。AID是一种胞苷脱氨酶，据信通过在Ig基因的单链DNA中分离胞苷残基来启动这些反应。这种反应有可能在非ig基因中产生DNA损伤，并使基因组不稳定。在这里，我们回顾了目前对AID如何靶向和突变Ig基因以及如何在SHM， CSR和GC中维持基因组完整性的理解。
Activation-induced deaminase (AID) is required for three distinct reactions crucial to the diversification of the antibody repertoire; these are somatic hypermutation (SHM), class switch recombination (CSR) and gene conversion (GC). AID is a cytidine deaminase and is believed to initiate these reactions by dearninating cytidine residues in single-stranded DNA in Ig genes. This reaction has the potential to produce DNA damage in non-Ig genes and to destabilize the genome. Here, we review the current understanding of how AID is targeted and mutates Ig genes and how genome integrity is maintained during SHM, CSR and GC.