CIRCADIAN-RHYTHMS OF EPINEPHRINE AND NOREPINEPHRINE IN MAN
CIRCADIAN-RHYTHMS OF EPINEPHRINE AND NOREPINEPHRINE IN MAN
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DOI：
10.1210/jcem-60-6-1210
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发表时间：
1985-01-01
影响因子：
5.8
通讯作者：
CAUSON, RC
中科院分区：
文献类型：
--
作者：
LINSELL, CR;LIGHTMAN, SL;CAUSON, RC
本文研究了一组正常青年男子血浆肾上腺素和去甲肾上腺素的昼夜节律。监测睡眠、姿势、光照和食物摄入量。血浆肾上腺素表现出统计学上显著的昼夜节律，平均幅度为14.+-。1.6(.+-.Se)pg/ml，平均为43.+-。5.3pg/ml，低谷出现在03.20h。35分钟。血浆去甲肾上腺素有明显的昼夜节律，平均幅度为111.+-。19 pg/ml，叠加平均水平413.+-。25pg/ml，低谷出现在0.20h+-。30分钟零相移时的两个节律之间存在显著的相关性，r=0.49。肾上腺素水平与睡眠或姿势没有直接关系；直立姿势时去甲肾上腺素水平显著高于睡眠时，男性清醒时的去甲肾上腺素水平高于睡眠时。显然，交感-肾上腺髓质系统的昼夜节律变化不是由单一的控制影响来解释的；去甲肾上腺素节律显然可以解释为对姿势和睡眠变化的直接反应，而肾上腺素节律可能是由昼夜节律振荡器控制的。
The diurnal rhythms of plasma epinephrine and norepinephrine were investigated in a group of normal young men. Sleep, posture, illumination and food intake were monitored. Plasma epinephrine demonstrated a statistically significant diurnal rhythm, with a mean amplitude of 14 .+-. 1.6 (.+-. SE) pg/ml superimposed on a mean level of 43 .+-. 5.3 pg/ml. The trough occurred at 03.20 h .+-. 35 min. Plasma norepinephrine had a significant diurnal rhythm, with a mean amplitude of 111 .+-. 19 pg/ml superimposed on a mean level of 413 .+-. 25 pg/ml, with the trough occurring at 0.20 h .+-. 30 min. There was a significant correlation between the 2 rhythms at zero phase shift, with a pooled value for the group of r = 0.49. Epinephrine levels had no direct relationship to sleep or posture; norepinephrine levels were significantly higher with upright posture and higher when the men were awake than when asleep. Apparently, circadian variations in the sympathetic-adrenl medullary system are not explained by a single controlling influence; the norepinephrine rhythm evidently can be accounted for as a direct response to changes in posture and sleep, whereas the epinephrine rhythm is probably controlled by a circadian oscillator.