Immuno-pathogenesis of Periodontal Disease: Current and Emerging Paradigms.
Immuno-pathogenesis of Periodontal Disease: Current and Emerging Paradigms.
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DOI：
10.1007/s40496-014-0017-8
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发表时间：
2014-06-01
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牙周病（PD）是一种涉及许多因素的高度复杂的疾病;然而，对大多数PD的起始和进展至关重要的两个主要方面是龈下菌斑中微生物的组成，以及宿主对这些生物体的免疫反应。许多研究指出PD的复杂性，以及尽管先天和适应性免疫激活以及由此产生的炎症，但我们的免疫反应无法治愈疾病的事实。令人惊叹的新发现已经开始澄清PD的宿主-病原体相互作用的几个复杂性，指出微生物失调和免疫失衡在疾病发病机制中的关键作用。此外，这些研究已经确定了新的翻译机会，以调解PD治疗。在这篇综述中，我们将重点介绍一些最近的研究结果，在先天性和适应性免疫，和宿主病原体的相互作用，PD在微环境水平，可能有深远的影响PD进展。
Periodontal disease (PD) is a highly complex disease involving many factors; however, two principal facets central to initiation and progression of the majority of PD are the composition of the microbes in the sub-gingival plaque, and the host immune response to these organisms. Numerous studies point to the complexity of PD, and to the fact that despite innate and adaptive immune activation, and resultant inflammation, our immune response fails to cure disease. Stunning new findings have begun to clarify several complexities of the host-pathogen interaction of PD pointing to key roles for microbial dysboisis and immune imbalance in the pathogenesis of disease. Furthermore, these investigations have identified novel translational opportunities to intercede in PD treatment. In this review we will highlight a select few recent findings in innate and adaptive immunity, and host pathogen interactions of PD at a micro-environmental level that may have profound impact on PD progression.