New triterpenoid saponins with strong α-glucosidase inhibitory activity from the roots of Gypsophila oldhamiana
New triterpenoid saponins with strong α-glucosidase inhibitory activity from the roots of Gypsophila oldhamiana
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DOI：
10.1016/j.bmc.2007.12.053
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发表时间：
2008-03-15
影响因子：
3.5
通讯作者：
Kong, Ling-Yi
中科院分区：
文献类型：
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作者：
Luo, Han-Guang;Ma, Li;Kong, Ling-Yi
从丝石竹（Gypsophila oldhamiana）根中分离鉴定了7个新的三萜皂苷（1 - 7）和5个已知的三萜皂苷（8 - 12）。这些皂苷可分为三个系列：3-O-单葡萄糖苷（1，8，9），28-O-单葡萄糖苷（24，12）和3，28-O-双桥糖苷（5 - 7，10，11）。结果表明，28-O-单葡萄糖苷2 - 4和12对α-葡萄糖苷酶具有明显的抑制活性。(C)2008爱思唯尔有限公司保留所有权利。
Seven new triterpenoid saponins (1-7), have been isolated and elucidated from the roots of Gypsophila oldhamiana together with five known triterpenoid saponins (8-12). These saponins which could be classified into three series: 3-O-monoglucosides (1, 8, 9), 28-O-monoglucosides (24, 12) and 3, 28-O-bidesmosides (5-7, 10, 11), have been evaluated for their a-glucosidase inhibition activity. As a result, the preliminary structure-activity relationships were discussed based on the position of sugar linkage attached to the aglycone, and 28-O-monoglucosides 2-4 and 12 showed significant inhibitory activities on a-glucosidase. (C) 2008 Elsevier Ltd. All rights reserved.