Comparison of neuroendocrine dysfunction in patients with adamantinomatous and papillary craniopharyngiomas
Comparison of neuroendocrine dysfunction in patients with adamantinomatous and papillary craniopharyngiomas
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DOI：
10.3892/etm.2018.6953
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发表时间：
2019-01-01
影响因子：
2.7
通讯作者：
Zhong, Li-Yong
中科院分区：
文献类型：
--
作者：
Feng, Ying;Ni, Ming;Zhong, Li-Yong
颅咽管瘤(CPS)是一种罕见的上皮性肿瘤，主要位于鞍区/鞍旁。它们可分为两大亚型：造釉细胞性CP(ACP)和乳头状CP(PCP)。本研究的目的是比较ACP和PCP手术切除前后的神经内分泌功能障碍。根据病理分类将患者分为ACP组和PCP组。手术前后采用评分方法对这两种CP亚型的神经内分泌功能障碍进行评估。本研究共纳入741例CPS患者，其中ACP 622例，PCP 119例。无论是否手术，PCP组的肿瘤体积效应、下丘脑功能障碍、垂体靶腺轴功能障碍以及中枢性尿崩症的发生率均显著高于ACP组(均P
Craniopharyngiomas (CPs) are rare epithelial tumors mainly located in the sellar/parasellar region. They may be classified into two major histological subtypes, which exhibit clinical and pathological differences: Adamantinomatous CP (ACP) and papillary CP (PCP). The aim of the present study was to compare the neuroendocrine dysfunction between ACP and PCP prior to and after surgical resection. According to their pathological classification, the patients were assigned to the ACP group or the PCP group. The neuroendocrine dysfunction in these two CP subtypes was evaluated using a scoring method prior to and after surgery. A total of 741 patients with CPs were included in the present study, of which 622 were ACP and 119 were PCP. The scores on the tumor mass effect, hypothalamic dysfunction and pituitary-target gland axis dysfunction, as well as the incidence of central diabetes insipidus in the PCP group were all significantly higher than those in the ACP group, regardless of whether the surgery had been performed or not (all P