Urinary iodine concentration and radioactive iodine therapeutic response in patients with differentiated thyroid cancer
Urinary iodine concentration and radioactive iodine therapeutic response in patients with differentiated thyroid cancer
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DOI：
10.2217/bmm-2020-0745
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发表时间：
2021-07-09
影响因子：
2.2
通讯作者：
Wang, Yan
中科院分区：
文献类型：
--
作者：
Jiang, Yuyan;Jin, Jiahui;Wang, Yan
目的：尿碘浓度(UIC)可作为评价放射性碘消融的指标。材料与方法：根据2015年美国甲状腺协会指南，将患者分为低至中风险组和高风险组。晨尿标本用高铈-亚砷酸法测定。结果：在中低危组(113例)，不良反应(Non-ER)与较高的UIC、较高的UIC亚组(p<；0.05)、较高的术前刺激甲状腺球蛋白水平(p<；0.01)相关。在高危组(68例)，消融前促甲状腺球蛋白水平越高，非ER率越高(p<；0.01)，但UIC亚组与UIC亚组之间差异无统计学意义(p>；0.05)。结论：中低危组非ER率与UIC相关，而高危组UIC不影响非ER率。
Aim: Urinary iodine concentration (UIC) may assess radioactive iodine ablation. Materials & methods: According the 2015 American Thyroid Association guidelines, patients were categorized into low- to intermediate-risk or high-risk groups. The iodine concentration in the morning urine specimens was measured by the ceric ion-arsenious acid method. Results: In the low- to intermediate-risk group (113 cases), nonexcellent response (non-ER) was associated with higher UIC, higher UIC subgroups (p < 0.05), higher pre-ablative stimulated thyroglobulin levels (p < 0.01). In the high-risk group (68 cases), the non-ER rate was higher in the higher pre-ablative stimulated thyroglobulin group (p < 0.01), but not significantly different between the UIC and UIC subgroups (p > 0.05). Conclusion: The non-ER rate was related to UIC in the low- to intermediate-risk group; however, UIC did not affect the non-ER rate in the high-risk group.