Multisensory integration in the ventral intraparietal area of the macaque monkey
Multisensory integration in the ventral intraparietal area of the macaque monkey
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DOI：
10.1523/jneurosci.2646-06.2007
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发表时间：
2007-02-21
影响因子：
5.3
通讯作者：
Duhamel, Jean-Rene
中科院分区：
文献类型：
--
作者：
Avillac, Marie;Ben Hamed, Suliann;Duhamel, Jean-Rene
本研究的目的是表征皮层腹侧顶内区（VIP）的多感觉相互作用模式。我们记录了两只警觉的猴子在呈现视觉（漂移光栅）和触觉（低压空气吹气）刺激时的单单元活动。一个刺激总是位于神经元的感受野。另一个刺激的定义是为了操纵两个刺激之间的时空差异。超过70%的VIP细胞在双峰刺激下表现出明显的反应调节。这些细胞包括双峰细胞，即对两种测试模式都有反应的细胞，以及看似单峰的细胞，即只对两种测试模式中的一种有反应的细胞。后一种观察表明突触后潜伏机制参与了多感觉统合。在这两种细胞类别中，神经元反应要么增强要么抑制，并反映非线性的亚、超或加性机制。当刺激在时间同步和空间一致时，这些观察的发生是最大的。有趣的是，在刺激之间引入空间或时间差异并不影响相互作用的符号或大小，而是影响它们的发生。多感觉刺激也会影响双峰刺激的神经元反应潜伏期。对于一个给定的神经元，这些反应潜伏期平均介于两个单峰反应潜伏期之间，再次表明潜在的突触后机制。总之，我们发现大多数VIP神经元执行多感觉整合，遵循一般规则（例如，空间一致性和时间同步性），这些规则与其他皮层和皮层下区域的描述非常相似。
The goal of this study was to characterize multisensory interaction patterns in cortical ventral intraparietal area (VIP). We recorded single-unit activity in two alert monkeys during the presentation of visual (drifting gratings) and tactile (low-pressure air puffs) stimuli. One stimulus was always positioned inside the receptive field of the neuron. The other stimulus was defined so as to manipulate the spatial and temporal disparity between the two stimuli. More than 70% of VIP cells showed a significant modulation of their response by bimodal stimulations. These cells included both bimodal cells, i.e., cells responsive to both tested modalities, and seemingly unimodal cells, i.e., cells responding to only one of the two tested modalities. This latter observation suggests that postsynaptic latent mechanisms are involved in multisensory integration. In both cell categories, neuronal responses are either enhanced or depressed and reflect nonlinear sub-, super-, or additive mechanisms. The occurrence of these observations is maximum when stimuli are in temporal synchrony and spatially congruent. Interestingly, introducing spatial or temporal disparities between stimuli does not affect the sign or the magnitude of interactions but rather their occurrence. Multisensory stimulation also affects the neuronal response latencies of bimodal stimuli. For a given neuron, these are on average intermediate between the two unimodal response latencies, again suggesting latent postsynaptic mechanisms. In summary, we show that the majority of VIP neurons perform multisensory integration, following general rules (e.g., spatial congruency and temporal synchrony) that are closely similar to those described in other cortical and subcortical regions.