Influence of latent 'asymptomatic' toxoplasmosis on body weight of pregnant women
Influence of latent 'asymptomatic' toxoplasmosis on body weight of pregnant women
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DOI：
10.14411/fp.2005.026
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发表时间：
2005-09-01
影响因子：
1.6
通讯作者：
Kodym, P
中科院分区：
文献类型：
--
作者：
Flegr, J;Hrdá, S;Kodym, P
潜伏的弓形虫病通常被认为是无症状的，然而，这种模式从未经过严格的测试。在这里，我们通过分析758名在妊娠第16周进行弓形虫病检测的妇女的临床记录，寻找感染者身体健康恶化的症状（体重下降）。弓形虫阳性孕妇妊娠第16周体重低于弓形虫阴性孕妇（p = 0.02）。此外，在174名弓形虫病阳性妇女中，体重与弓形虫病持续时间呈负相关（p = 0.04），这表明潜伏性弓形虫病的缓慢累积效应，而不是急性弓形虫病的短暂效应，是受感染受试者体重下降的原因。超声检测弓形虫阳性孕妇妊娠第16周末次月经后妊娠持续时间较长（p = 0.04），提示弓形虫阳性孕妇胎儿发育迟缓的可能性。潜伏性弓形虫病的患病率非常高。因此，即使是其轻微症状，如弓形虫阳性孕妇体重下降，实际上也可能表明未被认识到的严重公共卫生问题。
The latent toxoplasmosis is usually considered to be asymptomatic, however, this paradigm has never been rigorously tested. Here we searched for symptoms of deterioration of physical health (decrease of weight) in infected people by analysis of clinical records of 758 women tested for toxoplasmosis in the 16th week of gravidity. Toxoplasma-positive women have a lower body weight in the 16th week of gravidity (p = 0.02) than Toxoplasma-negative women. Moreover, a negative correlation between weight and the duration of toxoplasmosis was found in a subset of 174 Toxoplasina-positive women (p = 0.04), suggesting that slow and cumulative effects of latent toxoplasmosis, rather than a transient effect of acute toxoplasmosis, are responsible for the decreased weight of infected subjects. Longer duration of gravidity estimated from the date of last menstruation in the set of Toxoplasma-positive women in the 16th week of gravidity estimated with ultrasonography (p = 0.04) suggests a possibility of retarded foetal growth in Toxoplasma-positive women. The prevalence of latent toxoplasmosis is extremely high. Therefore, even its mild symptoms such as the decreased body weight in Toxoplasma-positive pregnant women might in fact indicate an unrecognized serious public health problem.