Genetic Variations in the PRKAA1 and ZBTB20 Genes and Gastric Cancer Susceptibility in a Korean Population
Genetic Variations in the PRKAA1 and ZBTB20 Genes and Gastric Cancer Susceptibility in a Korean Population
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DOI：
10.1002/mc.22063
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发表时间：
2013-11-01
影响因子：
4.6
通讯作者：
Shin, Min-Ho
中科院分区：
文献类型：
--
作者：
Song, Hye-Rim;Kim, Hee Nam;Shin, Min-Ho
最近的一项全基因组关联研究（GWAS）发现了新的易感性单核苷酸多态性（SNP）rs 13361707（5p13.1上的PRKAA 1和PTGER 4基因）和rs 9841504（3q13.31上的ZBTB 20基因），它们与非贲门胃癌显著相关。本研究的目的是确定韩国人群中rs 13361707和rs 9841504多态性是否与胃癌风险相关。我们对3245名胃癌患者和1700名对照者进行了一项大规模的病例对照研究。胃癌组rs 13361707 C和rs 9841504 G等位基因频率分别为53.5%和18.3%，对照组分别为47.1%和17.2%。我们发现rs 13361707 TC和CC基因型与胃癌风险增加相关（TC与TT的比值比[OR]=1.29; 95%置信区间[CI]=1.11-1.51，CC与TT的比值比[OR]= 1.68; 1.41-2.01）。然而，我们发现rs 9841504与胃癌风险之间没有显著相关性（CG vs. CC的OR=1.11; 0.97-1.28; GG vs. CC的OR=1.09; 0.77-1.53）。我们没有观察到rs 13361707和rs 9841504多态性与年龄、性别、吸烟习惯、饮酒和临床病理特征（如肿瘤解剖位置和组织学类型）之间的显著相互作用。我们的研究表明，在韩国人群中，rs 13361707多态性与胃癌风险增加相关。这一发现为PRKAA 1和PTGER 4基因的遗传变异可能参与胃癌的发生提供了进一步的证据。然而，我们发现rs 9841504与胃癌风险之间没有关联。(c)2013 Wiley Periodicals，Inc.
A recent genome-wide association study (GWAS) identified new susceptibility single-nucleotide polymorphisms (SNPs) rs13361707 (PRKAA1 and PTGER4 gene on 5p13.1) and rs9841504 (ZBTB20 gene on 3q13.31) that were significantly associated with non-cardia gastric cancer. The aim of this study was to determine whether rs13361707 and rs9841504 polymorphisms are associated with the risk of gastric cancer in a Korean population. We conducted a large-scale case-control study of 3245 gastric cancer patients and 1700 controls. The allele frequencies for rs13361707 C and rs9841504 G were 53.5% and 18.3% among gastric cancer cases, compared with 47.1% and 17.2% among controls, respectively. We found that rs13361707 TC and CC genotypes were associated with increased risk for gastric cancer (odds ratios [OR]=1.29; 95% confidence interval [CI]=1.11-1.51 for TC vs. TT and 1.68; 1.41-2.01 for CC vs. TT). However, we found no significant association between rs9841504 and gastric cancer risk (OR=1.11; 0.97-1.28 for CG vs. CC; OR=1.09; 0.77-1.53 for GG vs. CC). We observed no significant interactions between rs13361707 and rs9841504 polymorphisms and age, gender, smoking habit, alcohol consumption, and clinicopathologic characteristics such as anatomical tumor location and histological type. Our study showed that the rs13361707 polymorphism was associated with increased risk of gastric cancer in a Korean population. This finding provides further evidence that genetic variant of PRKAA1 and PTGER4 genes may contribute to the gastric carcinogenesis. However, we found no association between rs9841504 and gastric cancer risk. (c) 2013 Wiley Periodicals, Inc.